FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005447772> ?p ?o ?g. }

• W2005447772 endingPage "8894" @default.
• W2005447772 startingPage "8878" @default.
• W2005447772 abstract "Jeju ground water, containing vanadium compounds, was shown to increase glutathione (GSH) levels as determined by a colorimetric assay and confocal microscopy. To investigate whether the effects of Jeju ground water on GSH were specifically mediated by vanadium compounds, human Chang liver cells were incubated for 10 passages in media containing deionized distilled water (DDW), Jeju ground water (S1 and S3), and vanadyl sulfate (VOSO4). Vanadyl sulfate scavenged superoxide anion, hydroxyl radical and intracellular reactive oxygen species. Vanadyl sulfate effectively increased cellular GSH level and up-regulated mRNA and protein expression of a catalytic subunit of glutamate cysteine ligase (GCLC), which is involved in GSH synthesis. The induction of GCLC expression by vanadyl sulfate was found to be mediated by transcription factor erythroid transcription factor NF-E2 (Nrf2), which critically regulates GCLC by binding to the antioxidant response elements (AREs). Vanadyl sulfate treatment increased the nuclear translocation of Nrf2 and the accumulation of phosphorylated Nrf2. Extracellular regulated kinase (ERK) contributed to ARE-driven GCLC expression via Nrf2 activation. Vanadyl sulfate induced the expression of the active phospho form of ERK. Taken together, these results suggest that the increase in GSH level by Jeju ground water is, at least in part, due to the effects of vanadyl sulfate via the Nrf2-mediated induction of GCLC." @default.
• W2005447772 created "2016-06-24" @default.
• W2005447772 creator A5003418011 @default.
• W2005447772 creator A5014739246 @default.
• W2005447772 creator A5036596316 @default.
• W2005447772 creator A5060523780 @default.
• W2005447772 creator A5077588952 @default.
• W2005447772 date "2011-12-05" @default.
• W2005447772 modified "2023-09-25" @default.
• W2005447772 title "Increased Glutathione Synthesis Following Nrf2 Activation by Vanadyl Sulfate in Human Chang Liver Cells" @default.
• W2005447772 cites W1967782318 @default.
• W2005447772 cites W1973141016 @default.
• W2005447772 cites W1977926586 @default.
• W2005447772 cites W1987727847 @default.
• W2005447772 cites W1988517042 @default.
• W2005447772 cites W1998050555 @default.
• W2005447772 cites W2002897170 @default.
• W2005447772 cites W2011774955 @default.
• W2005447772 cites W2021734110 @default.
• W2005447772 cites W2024796877 @default.
• W2005447772 cites W2038376109 @default.
• W2005447772 cites W2040848489 @default.
• W2005447772 cites W2043069876 @default.
• W2005447772 cites W2044922802 @default.
• W2005447772 cites W2046757730 @default.
• W2005447772 cites W2051720270 @default.
• W2005447772 cites W2057379374 @default.
• W2005447772 cites W2059447116 @default.
• W2005447772 cites W2078769631 @default.
• W2005447772 cites W2081252835 @default.
• W2005447772 cites W2086555897 @default.
• W2005447772 cites W2088651962 @default.
• W2005447772 cites W2104138299 @default.
• W2005447772 cites W2138420210 @default.
• W2005447772 cites W2146558971 @default.
• W2005447772 cites W2156667412 @default.
• W2005447772 cites W2166337262 @default.
• W2005447772 cites W2169729819 @default.
• W2005447772 cites W2171362910 @default.
• W2005447772 doi "https://doi.org/10.3390/ijms12128878" @default.
• W2005447772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3257106" @default.
• W2005447772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22272109" @default.
• W2005447772 hasPublicationYear "2011" @default.
• W2005447772 type Work @default.
• W2005447772 sameAs 2005447772 @default.
• W2005447772 citedByCount "20" @default.
• W2005447772 countsByYear W20054477722013 @default.
• W2005447772 countsByYear W20054477722014 @default.
• W2005447772 countsByYear W20054477722015 @default.
• W2005447772 countsByYear W20054477722016 @default.
• W2005447772 countsByYear W20054477722017 @default.
• W2005447772 countsByYear W20054477722018 @default.
• W2005447772 countsByYear W20054477722019 @default.
• W2005447772 countsByYear W20054477722020 @default.
• W2005447772 countsByYear W20054477722021 @default.
• W2005447772 countsByYear W20054477722022 @default.
• W2005447772 countsByYear W20054477722023 @default.
• W2005447772 crossrefType "journal-article" @default.
• W2005447772 hasAuthorship W2005447772A5003418011 @default.
• W2005447772 hasAuthorship W2005447772A5014739246 @default.
• W2005447772 hasAuthorship W2005447772A5036596316 @default.
• W2005447772 hasAuthorship W2005447772A5060523780 @default.
• W2005447772 hasAuthorship W2005447772A5077588952 @default.
• W2005447772 hasBestOaLocation W20054477721 @default.
• W2005447772 hasConcept C153911025 @default.
• W2005447772 hasConcept C178790620 @default.
• W2005447772 hasConcept C179104552 @default.
• W2005447772 hasConcept C181199279 @default.
• W2005447772 hasConcept C184235292 @default.
• W2005447772 hasConcept C185592680 @default.
• W2005447772 hasConcept C2778343803 @default.
• W2005447772 hasConcept C2779881523 @default.
• W2005447772 hasConcept C2781116636 @default.
• W2005447772 hasConcept C2781173740 @default.
• W2005447772 hasConcept C504678139 @default.
• W2005447772 hasConcept C538909803 @default.
• W2005447772 hasConcept C55493867 @default.
• W2005447772 hasConcept C57074206 @default.
• W2005447772 hasConcept C79879829 @default.
• W2005447772 hasConcept C86803240 @default.
• W2005447772 hasConceptScore W2005447772C153911025 @default.
• W2005447772 hasConceptScore W2005447772C178790620 @default.
• W2005447772 hasConceptScore W2005447772C179104552 @default.
• W2005447772 hasConceptScore W2005447772C181199279 @default.
• W2005447772 hasConceptScore W2005447772C184235292 @default.
• W2005447772 hasConceptScore W2005447772C185592680 @default.
• W2005447772 hasConceptScore W2005447772C2778343803 @default.
• W2005447772 hasConceptScore W2005447772C2779881523 @default.
• W2005447772 hasConceptScore W2005447772C2781116636 @default.
• W2005447772 hasConceptScore W2005447772C2781173740 @default.
• W2005447772 hasConceptScore W2005447772C504678139 @default.
• W2005447772 hasConceptScore W2005447772C538909803 @default.
• W2005447772 hasConceptScore W2005447772C55493867 @default.
• W2005447772 hasConceptScore W2005447772C57074206 @default.
• W2005447772 hasConceptScore W2005447772C79879829 @default.
• W2005447772 hasConceptScore W2005447772C86803240 @default.
• W2005447772 hasIssue "12" @default.
• W2005447772 hasLocation W20054477721 @default.

• next