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- W2005449092 abstract "T cell immune function was further evaluated in cystic fibrosis (CF) patients. CF patients, regardless of severity of pulmonary disease or colonization with <i>Pseudomonas aeruginosa, </i>had lower percentages of T helper cells (p < 0.01) and decreased T helper function as demonstrated by diminished T help for control B cell pokeweed mitogen-stimulated IgG (p < 0.01) and IgM (p < 0.01) synthesis. Increased T suppressor function, measured by co-culture with control B and T cells, was noted in only 25% of CF patients. CF patients’ T cells exhibited decreased allogeneic T cell cytotoxicity compared to normal controls (p < 0.01). This study extends previous studies demonstrating decreased T cell functions in CF patients and indicates a specific decrease in T helper function." @default.
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- W2005449092 date "1988-01-01" @default.
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- W2005449092 title "Decreased T Helper Cell Function in Patients with Cystic Fibrosis" @default.
- W2005449092 doi "https://doi.org/10.1159/000234504" @default.
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