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• W2005451854 startingPage "1262" @default.
• W2005451854 abstract "Cardiovascular disease (CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of NO production and mediates anti-inflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore, this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity." @default.
• W2005451854 created "2016-06-24" @default.
• W2005451854 creator A5031441189 @default.
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• W2005451854 creator A5075473125 @default.
• W2005451854 date "2014-01-01" @default.
• W2005451854 modified "2023-09-26" @default.
• W2005451854 title "Implications of Klotho in vascular health and disease" @default.
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• W2005451854 doi "https://doi.org/10.4330/wjc.v6.i12.1262" @default.
• W2005451854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4278161" @default.
• W2005451854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25548616" @default.
• W2005451854 hasPublicationYear "2014" @default.
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