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• W2005453420 abstract "Phospholipase C (PLC) is a key enzyme that generates inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), two second messengers in signal transduction. Phospholipase Cε (PLCE1) is a unique member of the PLC family in that it carries both RasGEF and Ras-associating (RA) domains and may serve as an activator and an effector of small GTPases. Recently, mutations in PLCE1 have been associated with early-onset nephrotic syndrome. We have identified the zebrafish ortholog of PLCE1 and characterized its expression pattern in zebrafish embryos by in situ hybridization. Zebrafish plce1 gene encodes a protein of 2248 amino acids that shares 56% identity with mammalian PLCε. During zebrafish embryonic development, plce1 is expressed in a dynamic pattern in a variety of organs, such as brain, muscle, liver, and pronephric glomeruli. Our results suggest that zebrafish may be used as a model organism to address the function of PLCε during the development of these organs." @default.
• W2005453420 created "2016-06-24" @default.
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• W2005453420 creator A5079173500 @default.
• W2005453420 date "2009-06-01" @default.
• W2005453420 modified "2023-10-18" @default.
• W2005453420 title "Molecular cloning and expression of phospholipase C epsilon 1 in zebrafish" @default.
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• W2005453420 doi "https://doi.org/10.1016/j.gep.2009.03.003" @default.
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