FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005456367> ?p ?o ?g. }

• W2005456367 endingPage "1170" @default.
• W2005456367 startingPage "1159" @default.
• W2005456367 abstract "Cardiac hypertrophy is a predictor of cardiovascular morbidity and mortality independent of other risk factors. Pressure overload induces the development of left ventricular hypertrophy (LVH) and left atrial enlargement (LAE) in the mammalian heart. To systematically investigate the transcriptional changes, which mediate these processes, we have performed a genome-wide transcriptional profiling of each of the four heart chambers from mice subjected to transverse aortic constriction (TAC). A major new finding of this analysis is that during enlargement the left atrium undergoes radical changes in gene transcription that may play a significant role in pathophysiology. Structural changes in the LA and LV are correlated with significant changes in the transcriptional profile of these chambers, with thousands of differentially expressed known and novel factors. Statistical analysis of the results identified Gene Ontology biological process groups with significant group-wide changes, including angiogenesis, energy pathways, fatty acid oxidation, oxidative phosphorylation, cytoskeletal and matrix reorganization, and G-protein coupled receptor (GPCR) signaling. To facilitate future research, a searchable annotated Internet database has been constructed that allows access to the expression data presented here. Further study of these genes and processes will lead to better understanding of pathways involved in the pathophysiology of the cardiac response to pressure overload." @default.
• W2005456367 created "2016-06-24" @default.
• W2005456367 creator A5003281360 @default.
• W2005456367 creator A5007684135 @default.
• W2005456367 creator A5010197740 @default.
• W2005456367 creator A5028422920 @default.
• W2005456367 creator A5057606234 @default.
• W2005456367 date "2004-12-01" @default.
• W2005456367 modified "2023-09-23" @default.
• W2005456367 title "Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses" @default.
• W2005456367 cites W1510237593 @default.
• W2005456367 cites W1552118263 @default.
• W2005456367 cites W1796390619 @default.
• W2005456367 cites W1966187802 @default.
• W2005456367 cites W1968404111 @default.
• W2005456367 cites W1969210306 @default.
• W2005456367 cites W1972271676 @default.
• W2005456367 cites W1972468352 @default.
• W2005456367 cites W1975522586 @default.
• W2005456367 cites W1975717275 @default.
• W2005456367 cites W1979363352 @default.
• W2005456367 cites W1980475208 @default.
• W2005456367 cites W1982469210 @default.
• W2005456367 cites W1988139909 @default.
• W2005456367 cites W1997773937 @default.
• W2005456367 cites W2008434058 @default.
• W2005456367 cites W2025087506 @default.
• W2005456367 cites W2029673496 @default.
• W2005456367 cites W2038629624 @default.
• W2005456367 cites W2050822891 @default.
• W2005456367 cites W2051155595 @default.
• W2005456367 cites W2051767039 @default.
• W2005456367 cites W2052763120 @default.
• W2005456367 cites W2053818267 @default.
• W2005456367 cites W2058215209 @default.
• W2005456367 cites W2070510225 @default.
• W2005456367 cites W2080498663 @default.
• W2005456367 cites W2080814134 @default.
• W2005456367 cites W2085306336 @default.
• W2005456367 cites W2087133841 @default.
• W2005456367 cites W2099093659 @default.
• W2005456367 cites W2101112263 @default.
• W2005456367 cites W2103923249 @default.
• W2005456367 cites W2104740972 @default.
• W2005456367 cites W2105014609 @default.
• W2005456367 cites W2109041435 @default.
• W2005456367 cites W2110295814 @default.
• W2005456367 cites W2123796764 @default.
• W2005456367 cites W2124408646 @default.
• W2005456367 cites W2127938920 @default.
• W2005456367 cites W2129439677 @default.
• W2005456367 cites W2131374289 @default.
• W2005456367 cites W2131676053 @default.
• W2005456367 cites W2139032664 @default.
• W2005456367 cites W2139186800 @default.
• W2005456367 cites W2139703939 @default.
• W2005456367 cites W2145944075 @default.
• W2005456367 cites W2146729193 @default.
• W2005456367 cites W2150171020 @default.
• W2005456367 cites W2151489843 @default.
• W2005456367 cites W2151591273 @default.
• W2005456367 cites W2153206163 @default.
• W2005456367 cites W2157795344 @default.
• W2005456367 cites W2165737207 @default.
• W2005456367 cites W2166654641 @default.
• W2005456367 cites W2171625957 @default.
• W2005456367 cites W2186290882 @default.
• W2005456367 cites W2204711925 @default.
• W2005456367 cites W2315578925 @default.
• W2005456367 cites W2329306090 @default.
• W2005456367 cites W76085819 @default.
• W2005456367 cites W2748413158 @default.
• W2005456367 cites W3128370515 @default.
• W2005456367 doi "https://doi.org/10.1016/j.yjmcc.2004.09.003" @default.
• W2005456367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15572046" @default.
• W2005456367 hasPublicationYear "2004" @default.
• W2005456367 type Work @default.
• W2005456367 sameAs 2005456367 @default.
• W2005456367 citedByCount "42" @default.
• W2005456367 countsByYear W20054563672012 @default.
• W2005456367 countsByYear W20054563672014 @default.
• W2005456367 countsByYear W20054563672015 @default.
• W2005456367 countsByYear W20054563672018 @default.
• W2005456367 countsByYear W20054563672019 @default.
• W2005456367 countsByYear W20054563672020 @default.
• W2005456367 countsByYear W20054563672021 @default.
• W2005456367 crossrefType "journal-article" @default.
• W2005456367 hasAuthorship W2005456367A5003281360 @default.
• W2005456367 hasAuthorship W2005456367A5007684135 @default.
• W2005456367 hasAuthorship W2005456367A5010197740 @default.
• W2005456367 hasAuthorship W2005456367A5028422920 @default.
• W2005456367 hasAuthorship W2005456367A5057606234 @default.
• W2005456367 hasConcept C104317684 @default.
• W2005456367 hasConcept C106208931 @default.
• W2005456367 hasConcept C126322002 @default.
• W2005456367 hasConcept C134018914 @default.
• W2005456367 hasConcept C135763542 @default.
• W2005456367 hasConcept C150194340 @default.

• next