FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005459775> ?p ?o ?g. }

• W2005459775 endingPage "1058" @default.
• W2005459775 startingPage "1051" @default.
• W2005459775 abstract "Adenoid cystic carcinoma (ACC) is one of the most common malignancies of salivary glands, characterized by poor prognosis, particularly due to pulmonary metastasis. We previously reported that transforming growth factor (TGF)-β1 promoted ACC cell migration and invasion via the Smad pathway in vitro. The aim of this study was to establish the underlying mechanisms. TGF-β1, phospho-Smad2 and β-catenin expression in ACC tissues derived from patients was evaluated by immunohistochemistry. The role of TGF- β1 on the invasive capacity of ACC cells was determined by transwell assays in SACC-83 cells transfected with TGF-β1 and TGF-β type II dominant-negative receptor (TβRIIDN) plasmids or silenced by TGF-β1 siRNA. Expression of the epithelial–mesenchymal transition (EMT) markers, β-catenin, E-cadherin and Nectin-1, was determined by real-time PCR and immunochemistry. In vivo investigations were performed by inoculating nude mice with the transfected ACC cells and examining metastasis in bilateral lung tissues by immunohistochemistry. Overexpression of TGF-β1 and phospho-Smad2, and reduced expression of membrane β-catenin, were closely associated with lung metastasis in ACC. Furthermore, the EMT markers were downregulated. In vitro, cells transfected with TGF-β1 exhibited altered morphology and increased invasive capacity compared to TβRIIDN-transfected cells or TGF-β1 siRNA silenced cells. In vivo, mice inoculated with TGF-β1 transfected ACC cells exhibited more metastases than other cells. TGF-β1, phospho-Smad2 and β-catenin were significantly correlated with ACC metastasis. Blockade of TGF-β signaling by TβRIIDN or siRNA may offer potential gene therapies against pulmonary metastasis in patients with ACC." @default.
• W2005459775 created "2016-06-24" @default.
• W2005459775 creator A5018144973 @default.
• W2005459775 creator A5025258443 @default.
• W2005459775 creator A5028558304 @default.
• W2005459775 creator A5032937513 @default.
• W2005459775 creator A5051613807 @default.
• W2005459775 creator A5065473593 @default.
• W2005459775 creator A5066463949 @default.
• W2005459775 creator A5082812729 @default.
• W2005459775 date "2013-11-01" @default.
• W2005459775 modified "2023-10-06" @default.
• W2005459775 title "Transforming growth factor-β and epithelial–mesenchymal transition are associated with pulmonary metastasis in adenoid cystic carcinoma" @default.
• W2005459775 cites W1970640991 @default.
• W2005459775 cites W1971830841 @default.
• W2005459775 cites W1982881537 @default.
• W2005459775 cites W1998319445 @default.
• W2005459775 cites W2000608450 @default.
• W2005459775 cites W2012919091 @default.
• W2005459775 cites W2014047844 @default.
• W2005459775 cites W2019030762 @default.
• W2005459775 cites W2035376807 @default.
• W2005459775 cites W2035653659 @default.
• W2005459775 cites W2049394248 @default.
• W2005459775 cites W2049861779 @default.
• W2005459775 cites W2050459519 @default.
• W2005459775 cites W2052007872 @default.
• W2005459775 cites W2060315334 @default.
• W2005459775 cites W2085482021 @default.
• W2005459775 cites W2094154487 @default.
• W2005459775 cites W2147865927 @default.
• W2005459775 cites W2156603098 @default.
• W2005459775 cites W2163043134 @default.
• W2005459775 cites W4240695995 @default.
• W2005459775 doi "https://doi.org/10.1016/j.oraloncology.2013.07.012" @default.
• W2005459775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23962790" @default.
• W2005459775 hasPublicationYear "2013" @default.
• W2005459775 type Work @default.
• W2005459775 sameAs 2005459775 @default.
• W2005459775 citedByCount "26" @default.
• W2005459775 countsByYear W20054597752014 @default.
• W2005459775 countsByYear W20054597752015 @default.
• W2005459775 countsByYear W20054597752016 @default.
• W2005459775 countsByYear W20054597752017 @default.
• W2005459775 countsByYear W20054597752018 @default.
• W2005459775 countsByYear W20054597752019 @default.
• W2005459775 countsByYear W20054597752020 @default.
• W2005459775 countsByYear W20054597752021 @default.
• W2005459775 countsByYear W20054597752022 @default.
• W2005459775 countsByYear W20054597752023 @default.
• W2005459775 crossrefType "journal-article" @default.
• W2005459775 hasAuthorship W2005459775A5018144973 @default.
• W2005459775 hasAuthorship W2005459775A5025258443 @default.
• W2005459775 hasAuthorship W2005459775A5028558304 @default.
• W2005459775 hasAuthorship W2005459775A5032937513 @default.
• W2005459775 hasAuthorship W2005459775A5051613807 @default.
• W2005459775 hasAuthorship W2005459775A5065473593 @default.
• W2005459775 hasAuthorship W2005459775A5066463949 @default.
• W2005459775 hasAuthorship W2005459775A5082812729 @default.
• W2005459775 hasConcept C118131993 @default.
• W2005459775 hasConcept C121608353 @default.
• W2005459775 hasConcept C126322002 @default.
• W2005459775 hasConcept C134018914 @default.
• W2005459775 hasConcept C142724271 @default.
• W2005459775 hasConcept C2777546739 @default.
• W2005459775 hasConcept C2779013556 @default.
• W2005459775 hasConcept C2779231225 @default.
• W2005459775 hasConcept C502942594 @default.
• W2005459775 hasConcept C54009773 @default.
• W2005459775 hasConcept C54355233 @default.
• W2005459775 hasConcept C71924100 @default.
• W2005459775 hasConcept C76419328 @default.
• W2005459775 hasConcept C81885089 @default.
• W2005459775 hasConcept C86803240 @default.
• W2005459775 hasConceptScore W2005459775C118131993 @default.
• W2005459775 hasConceptScore W2005459775C121608353 @default.
• W2005459775 hasConceptScore W2005459775C126322002 @default.
• W2005459775 hasConceptScore W2005459775C134018914 @default.
• W2005459775 hasConceptScore W2005459775C142724271 @default.
• W2005459775 hasConceptScore W2005459775C2777546739 @default.
• W2005459775 hasConceptScore W2005459775C2779013556 @default.
• W2005459775 hasConceptScore W2005459775C2779231225 @default.
• W2005459775 hasConceptScore W2005459775C502942594 @default.
• W2005459775 hasConceptScore W2005459775C54009773 @default.
• W2005459775 hasConceptScore W2005459775C54355233 @default.
• W2005459775 hasConceptScore W2005459775C71924100 @default.
• W2005459775 hasConceptScore W2005459775C76419328 @default.
• W2005459775 hasConceptScore W2005459775C81885089 @default.
• W2005459775 hasConceptScore W2005459775C86803240 @default.
• W2005459775 hasIssue "11" @default.
• W2005459775 hasLocation W20054597751 @default.
• W2005459775 hasLocation W20054597752 @default.
• W2005459775 hasOpenAccess W2005459775 @default.
• W2005459775 hasPrimaryLocation W20054597751 @default.
• W2005459775 hasRelatedWork W1696018979 @default.
• W2005459775 hasRelatedWork W1964681893 @default.
• W2005459775 hasRelatedWork W2323310996 @default.
• W2005459775 hasRelatedWork W2361638043 @default.

• next