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• W2005462824 endingPage "10830" @default.
• W2005462824 startingPage "10826" @default.
• W2005462824 abstract "We have studied the assembly of a large heterodimeric protein, bacterial luciferase, by mixing purified subunits expressed separately in bacteria. The individual subunits alpha and beta contain much (66% and 50%, respectively) of the alpha-helix content of the native heterodimer as measured by circular dichroism, yet the alpha subunit lacks observable tertiary structure as measured by NMR. These results are consistent with the alpha subunit existing in a molten globule or collapsed form prior to assembly. The molecular chaperone GroEL binds reversibly to both subunits prior to assembly. Since these observations were obtained under physiological conditions, we propose that the molten globule exists as a stable form during folding or assembly in the cell. Either the molten globule form of the subunits is an authentic folding intermediate or it is in rapid equilibrium with one. GroEL may function by facilitating assembly through stabilization of these incompletely folded subunits." @default.
• W2005462824 created "2016-06-24" @default.
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• W2005462824 date "1993-11-15" @default.
• W2005462824 modified "2023-09-26" @default.
• W2005462824 title "Individual subunits of bacterial luciferase are molten globules and interact with molecular chaperones." @default.
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• W2005462824 doi "https://doi.org/10.1073/pnas.90.22.10826" @default.
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