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• W2005463933 startingPage "S206" @default.
• W2005463933 abstract "In asurvey of data on 3,506 patients treated with tobramycin, the 21 cases of drugrelated ototoxicity are reported and reviewed. In seven patients the effects were auditory only, in nine vestibular only, and in five both auditory and vestibular. Effects subsided in 14 of the 18 patients who were available for monitoring after therapy. High-frequency audiometric losses persisted in three patients, and a hearing decrease persisted in one. In only one of the three patients did audiometric losses exceed 40 decibels. The patients with drug-related ototoxicity were compared to a group of 49 patients for whom both audiometric testing (before and after therapy) and clinical observation showed that no ototoxic reactions had occurred. Preexisting renal impairment, prior and/ or concomitant therapy with other possibly ototoxic drugs, and therapy for 10 days or more with a dose of >3 mg/kg per day were found to be associated with ototoxicity." @default.
• W2005463933 created "2016-06-24" @default.
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• W2005463933 date "1976-08-01" @default.
• W2005463933 modified "2023-09-25" @default.
• W2005463933 title "Ototoxicity of Tobramycin: A Clinical Overview" @default.
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• W2005463933 doi "https://doi.org/10.1093/infdis/134.supplement_1.s206" @default.
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