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- W2005468750 abstract "The oxidation of some cyanocycloheptatrienes with CrO3 and pyridine was investigated and a few new nitrile functionalised benzotropone derivatives were obtained. Photooxygenation reaction of these products was also studied. The structures of the formed products were determined on the basis of NMR spectroscopy and the formation mechanism of unusual products was discussed. Human carbonic anhydrase isoenzymes I, and II (hCA I and hCA II) inhibition properties of nitrile functionalized new benzotropone derivatives were also studied. Both CA isozymes were inhibited in the low micromolar range by these nitrile functionalized benzotropone analogues. The newly synthesized benzotropone derivatives showed inhibition constants in the sub-micromolar range (2.51–4.06 μM). The best hCA I inhibition was observed in 5H-benzocycloheptene-7-carbonitrile (Ki: 2.88 ± 0.86 μM). On the other hand, 5-oxo-5H-benzocycloheptatriene-7-carbonitrile showed the powerful inhibitory effect against hCA II (Ki: 2.51 ± 0.34 μM)." @default.
- W2005468750 created "2016-06-24" @default.
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- W2005468750 creator A5050370140 @default.
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- W2005468750 date "2014-07-01" @default.
- W2005468750 modified "2023-10-01" @default.
- W2005468750 title "Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives" @default.
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- W2005468750 doi "https://doi.org/10.1016/j.bmc.2014.04.007" @default.
- W2005468750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24856184" @default.
- W2005468750 hasPublicationYear "2014" @default.
- W2005468750 type Work @default.