Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005471852> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2005471852 endingPage "227" @default.
- W2005471852 startingPage "218" @default.
- W2005471852 abstract "The neuraminidases (NANases) of six strains of mumps virus were characterized biochemically. Though the hemagglutinin-neuraminidase (HN) glycoproteins were similar in apparent size and immunological properties, the NANase activities exhibited different behavior. Each NANase had a characteristic pH optimum and thermal stability. Kinetic analyses demonstrated unique Km catalytic constants, and Ki (Cl−) values for the different NANases. Three strains, Enders, RW, and O'Take, had active NANases (V′max = 179–680 nmol/min/mg virus protein) that hydrolyzed 37–50% of the total neuraminic acid (NANA) of fetuin; the other strains, Kilham, MJ, and Jeryl Lynn B, had less active NANases (V′max = 48–95 nmol/min/mg) capable of hydrolyzing only 10–27% NANA of fetuin. The virus hemagglutination activities (HA) and the elution rates for adsorbed virions were consistent with the NANase properties. Enders, RW, and O'Take strains agglutinated erythrocytes most efficiently at physiological NaCl concentration; HA activities for Kilham, MJ, and Jeryl Lynn B strains were not affected by NaCl concentration. Adsorbed Enders, RW, and O'Take virus eluted more rapidly from erythrocytes than did adsorbed Kilham, MJ, and Jeryl Lynn B strains. These properties, associated with the HN glycoprotein, are correlated with the cytopathogenicity of the strains. The O'Take and RW strains cause no cell fusion and little cytopathology; Kilham, MJ, and Jeryl Lynn B strains produce extensive cell fusion after infection of CV-1 cells. These results suggest that, in concert with the paramyxovirus fusion (F) glycoprotein, the viral NANase contributes to the cytopathology of an infection, an active NANase promoting rapid release of progeny virions, so that no cell fusion occurs, and the action of a less active NANase prolonging the association of progeny virus with the infected cell surface, increasing the likelihood of cell fusion." @default.
- W2005471852 created "2016-06-24" @default.
- W2005471852 creator A5018902911 @default.
- W2005471852 creator A5036852802 @default.
- W2005471852 date "1981-10-01" @default.
- W2005471852 modified "2023-09-23" @default.
- W2005471852 title "Biochemical features of mumps virus neuraminidases and their relationship with pathogenicity" @default.
- W2005471852 cites W1603150204 @default.
- W2005471852 cites W197484714 @default.
- W2005471852 cites W1976907921 @default.
- W2005471852 cites W1986544125 @default.
- W2005471852 cites W2004081383 @default.
- W2005471852 cites W2005235005 @default.
- W2005471852 cites W2015238086 @default.
- W2005471852 cites W2019942627 @default.
- W2005471852 cites W2028805675 @default.
- W2005471852 cites W2031303225 @default.
- W2005471852 cites W2031423487 @default.
- W2005471852 cites W2042489070 @default.
- W2005471852 cites W2043473204 @default.
- W2005471852 cites W2046244522 @default.
- W2005471852 cites W2077518626 @default.
- W2005471852 cites W2130798837 @default.
- W2005471852 cites W2153085755 @default.
- W2005471852 cites W2160222150 @default.
- W2005471852 cites W2328944885 @default.
- W2005471852 doi "https://doi.org/10.1016/0042-6822(81)90267-1" @default.
- W2005471852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7281513" @default.
- W2005471852 hasPublicationYear "1981" @default.
- W2005471852 type Work @default.
- W2005471852 sameAs 2005471852 @default.
- W2005471852 citedByCount "61" @default.
- W2005471852 countsByYear W20054718522013 @default.
- W2005471852 countsByYear W20054718522014 @default.
- W2005471852 countsByYear W20054718522015 @default.
- W2005471852 countsByYear W20054718522016 @default.
- W2005471852 countsByYear W20054718522018 @default.
- W2005471852 countsByYear W20054718522020 @default.
- W2005471852 countsByYear W20054718522022 @default.
- W2005471852 countsByYear W20054718522023 @default.
- W2005471852 crossrefType "journal-article" @default.
- W2005471852 hasAuthorship W2005471852A5018902911 @default.
- W2005471852 hasAuthorship W2005471852A5036852802 @default.
- W2005471852 hasConcept C108625454 @default.
- W2005471852 hasConcept C134164806 @default.
- W2005471852 hasConcept C1491633281 @default.
- W2005471852 hasConcept C153911025 @default.
- W2005471852 hasConcept C159047783 @default.
- W2005471852 hasConcept C2522874641 @default.
- W2005471852 hasConcept C2778541144 @default.
- W2005471852 hasConcept C2778692840 @default.
- W2005471852 hasConcept C2781302033 @default.
- W2005471852 hasConcept C34343649 @default.
- W2005471852 hasConcept C55493867 @default.
- W2005471852 hasConcept C86803240 @default.
- W2005471852 hasConcept C89423630 @default.
- W2005471852 hasConcept C92488253 @default.
- W2005471852 hasConceptScore W2005471852C108625454 @default.
- W2005471852 hasConceptScore W2005471852C134164806 @default.
- W2005471852 hasConceptScore W2005471852C1491633281 @default.
- W2005471852 hasConceptScore W2005471852C153911025 @default.
- W2005471852 hasConceptScore W2005471852C159047783 @default.
- W2005471852 hasConceptScore W2005471852C2522874641 @default.
- W2005471852 hasConceptScore W2005471852C2778541144 @default.
- W2005471852 hasConceptScore W2005471852C2778692840 @default.
- W2005471852 hasConceptScore W2005471852C2781302033 @default.
- W2005471852 hasConceptScore W2005471852C34343649 @default.
- W2005471852 hasConceptScore W2005471852C55493867 @default.
- W2005471852 hasConceptScore W2005471852C86803240 @default.
- W2005471852 hasConceptScore W2005471852C89423630 @default.
- W2005471852 hasConceptScore W2005471852C92488253 @default.
- W2005471852 hasIssue "1" @default.
- W2005471852 hasLocation W20054718521 @default.
- W2005471852 hasLocation W20054718522 @default.
- W2005471852 hasOpenAccess W2005471852 @default.
- W2005471852 hasPrimaryLocation W20054718521 @default.
- W2005471852 hasRelatedWork W1981662093 @default.
- W2005471852 hasRelatedWork W1993472930 @default.
- W2005471852 hasRelatedWork W2030685779 @default.
- W2005471852 hasRelatedWork W2036570018 @default.
- W2005471852 hasRelatedWork W2069776817 @default.
- W2005471852 hasRelatedWork W2183071545 @default.
- W2005471852 hasRelatedWork W2410710535 @default.
- W2005471852 hasRelatedWork W249099814 @default.
- W2005471852 hasRelatedWork W2804971835 @default.
- W2005471852 hasRelatedWork W3005563785 @default.
- W2005471852 hasVolume "114" @default.
- W2005471852 isParatext "false" @default.
- W2005471852 isRetracted "false" @default.
- W2005471852 magId "2005471852" @default.
- W2005471852 workType "article" @default.