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• W2005472690 abstract "Autoimmune regulator (AIRE) is a transcription factor expressed in the thymic medullary epithelial cells (MECs). MECs have been suggested to contribute to tolerance induction by presenting tissue specific antigens to T cells that react to these antigens. AIRE expression in cells other than MECs has not been studied extensively. Here we report four-color flow cytometric and quantitative real-time PCR studies on the expression of AIRE in the lymphoid cells in the thymus and periphery. In the thymus AIRE was expressed in B cells and CD4+CD8+ double positive cells at a low level. In the peripheral blood AIRE was expressed in B cells but not in T cells, and also expressed in CD14+ dendritic cells (DCs)/macrophages and granulocytes at higher levels. AIRE mRNA was expressed higher in B cells than in T cells. Further study is warranted to define the functional role of the AIRE expressed in the lymphoid cells." @default.
• W2005472690 created "2016-06-24" @default.
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• W2005472690 date "2008-01-01" @default.
• W2005472690 modified "2023-10-03" @default.
• W2005472690 title "Expression of AIRE in thymocytes and peripheral lymphocytes" @default.
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• W2005472690 doi "https://doi.org/10.1080/08916930701773941" @default.
• W2005472690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18324482" @default.
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