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• W2005473631 endingPage "1009" @default.
• W2005473631 startingPage "997" @default.
• W2005473631 abstract "Asthma is characterized by variable degrees of chronic inflammation and structural alterations in the airways. The most prominent abnormalities include epithelial denudation, goblet cell metaplasia, subepithelial thickening, increased airway smooth muscle mass, bronchial gland enlargement, angiogenesis, and alterations in extracellular matrix components, involving large and small airways. Chronic inflammation is thought to initiate and perpetuate cycles of tissue injury and repair in asthma, although remodeling may also occur in parallel with inflammation. In the absence of definite evidence on how different remodeling features affect lung function in asthma, the working hypothesis should be that structural alterations can lead to the development of persistent airway hyperresponsiveness and fixed airway obstruction. It is still unanswered whether and when to begin treating patients with asthma to prevent or reverse deleterious remodeling, which components of remodeling to target, and how to monitor remodeling. Consequently, efforts are being made to understand better the effects of conventional anti-inflammatory therapies, such as glucocorticosteroids, on airway structural changes. Animal models, in vitro studies, and some clinical studies have advanced present knowledge on the cellular and molecular pathways involved in airway remodeling. This has encouraged the development of biologicals aimed to target various components of airway remodeling. Progress in this area requires the explicit linking of modern structure-function analysis with innovative biopharmaceutical approaches." @default.
• W2005473631 created "2016-06-24" @default.
• W2005473631 creator A5000103333 @default.
• W2005473631 creator A5014004888 @default.
• W2005473631 creator A5052168220 @default.
• W2005473631 date "2007-11-01" @default.
• W2005473631 modified "2023-09-25" @default.
• W2005473631 title "Asthma therapy and airway remodeling" @default.
• W2005473631 cites W1634069075 @default.
• W2005473631 cites W1839982681 @default.
• W2005473631 cites W1883277602 @default.
• W2005473631 cites W1894440115 @default.
• W2005473631 cites W1900945426 @default.
• W2005473631 cites W1964510097 @default.
• W2005473631 cites W1965150731 @default.
• W2005473631 cites W1967722955 @default.
• W2005473631 cites W1970648068 @default.
• W2005473631 cites W1972808016 @default.
• W2005473631 cites W1973163755 @default.
• W2005473631 cites W1973304472 @default.
• W2005473631 cites W1976301049 @default.
• W2005473631 cites W1976911328 @default.
• W2005473631 cites W1978265226 @default.
• W2005473631 cites W1979235985 @default.
• W2005473631 cites W1979914322 @default.
• W2005473631 cites W1982140654 @default.
• W2005473631 cites W1982835289 @default.
• W2005473631 cites W1985778503 @default.
• W2005473631 cites W1987639012 @default.
• W2005473631 cites W1989260226 @default.
• W2005473631 cites W1989423035 @default.
• W2005473631 cites W1991246311 @default.
• W2005473631 cites W1991886932 @default.
• W2005473631 cites W1993768080 @default.
• W2005473631 cites W1999788260 @default.
• W2005473631 cites W2002423800 @default.
• W2005473631 cites W2006705655 @default.
• W2005473631 cites W2006842584 @default.
• W2005473631 cites W2012813253 @default.
• W2005473631 cites W2014913927 @default.
• W2005473631 cites W2018123076 @default.
• W2005473631 cites W2018892195 @default.
• W2005473631 cites W2018920420 @default.
• W2005473631 cites W2022952764 @default.
• W2005473631 cites W2024812229 @default.
• W2005473631 cites W2025232743 @default.
• W2005473631 cites W2026030771 @default.
• W2005473631 cites W2027400374 @default.
• W2005473631 cites W2029622575 @default.
• W2005473631 cites W2030685975 @default.
• W2005473631 cites W2031880739 @default.
• W2005473631 cites W2032735800 @default.
• W2005473631 cites W2035354847 @default.
• W2005473631 cites W2036472115 @default.
• W2005473631 cites W2038436322 @default.
• W2005473631 cites W2038629059 @default.
• W2005473631 cites W2039430024 @default.
• W2005473631 cites W2043938708 @default.
• W2005473631 cites W2044004206 @default.
• W2005473631 cites W2047622007 @default.
• W2005473631 cites W2049450894 @default.
• W2005473631 cites W2051661228 @default.
• W2005473631 cites W2053444611 @default.
• W2005473631 cites W2053568297 @default.
• W2005473631 cites W2053721760 @default.
• W2005473631 cites W2053724325 @default.
• W2005473631 cites W2054496526 @default.
• W2005473631 cites W2056705160 @default.
• W2005473631 cites W2059851645 @default.
• W2005473631 cites W2061096737 @default.
• W2005473631 cites W2064563647 @default.
• W2005473631 cites W2065803163 @default.
• W2005473631 cites W2071508654 @default.
• W2005473631 cites W2072173344 @default.
• W2005473631 cites W2074001528 @default.
• W2005473631 cites W2076431132 @default.
• W2005473631 cites W2077083859 @default.
• W2005473631 cites W2082695886 @default.
• W2005473631 cites W2083788682 @default.
• W2005473631 cites W2084074153 @default.
• W2005473631 cites W2090288719 @default.
• W2005473631 cites W2092222859 @default.
• W2005473631 cites W2093844921 @default.
• W2005473631 cites W2093883883 @default.
• W2005473631 cites W2094742854 @default.
• W2005473631 cites W2096018298 @default.
• W2005473631 cites W2097490698 @default.
• W2005473631 cites W2097536640 @default.
• W2005473631 cites W2098968578 @default.
• W2005473631 cites W2102175857 @default.
• W2005473631 cites W2102416816 @default.
• W2005473631 cites W2105973978 @default.
• W2005473631 cites W2106034623 @default.
• W2005473631 cites W2106927983 @default.
• W2005473631 cites W2109684002 @default.
• W2005473631 cites W2110244387 @default.
• W2005473631 cites W2110799130 @default.
• W2005473631 cites W2111923806 @default.

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