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- W2005473897 abstract "Use of theophylline (T) for apnea prompted development of a rapid, sensitive, selective microassay. Antiserum was raised in a goat, characterized, found to be highly specific for T and sensitive to 2 ng. Affinity of the antiserum and it's titer allowed routine assay of 2 ul plasma samples. The assay also has been adapted for use with 6 mm whole blood spots on filter paper. Plasma T levels two hours after 4 mg/kg per rectum maintenance doses (after loading doses of 8 mg/kg of aminophylline) ranged from 6-20 ug/ml (N=14). Terminal half-lives ranged from 12-54 hrs (30±5 hr, N=6). Cord samples from 75 consecutive deliveries were assayed for T and for caffeine (C) with antiserum supplied by C. E. Cook, Research Triangle inst.; T ranged from 0.04 to 2.9 and C from 0.01 to 3.4 ug/ml, distributed as follows: Conclusions: RIA is a valuable method for assay of methyl-xanthines. Doses of T used in this study produced plasma levels which appear to be safe and effective. T half-life is variable and markedly prolonged in prematures, in agreement with studies using other assay methods. At least 50% of our perinatal population is exposed to C levels known to be pharmacologically active in adults." @default.
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- W2005473897 date "1977-04-01" @default.
- W2005473897 modified "2023-10-18" @default.
- W2005473897 title "RADIOIMMUNOASSAY (RIA) FOR THEOPHYLLINE AND CAFFEINE: APPLICATION TO STUDIES IN THE FETUS AND NEWBORN" @default.
- W2005473897 doi "https://doi.org/10.1203/00006450-197704000-00296" @default.
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