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• W2005473956 abstract "An N-hydroxy analogue of 3,4-methylendioxymethamphetamine (MDMA), N-hydroxy MDMA (N-OH MDMA), has recently been distributed as a new designer drug in some drug markets. Very little data is available to the metabolic and pharmacological properties of N-OH MDMA, although it has been reported that the N-demethyl analogue, N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA), is mainly metabolized to MDA in rats. In this study, an analytical method for the determination of N-OH MDMA and its metabolites in biological samples was developed, and the metabolic properties of N-OH MDMA in rats were investigated. After the i.p. administration of N-OH MDMA to pigmented hairy rats (5 mg/kg/day, 10 days), N-OH MDMA and its N-dehydroxy and N-demethyl metabolites (MDMA, N-OH MDA and MDA) in rat plasma, urine and hair samples were determined by ultra-performance LC (UPLC)–MS/MS. The hair sample was extracted by 1-h sonication and overnight soaking in 5 M hydrochloric acid–methanol (1:20). The plasma, urine, and hair extract samples were purified using a solid-phase extraction procedure. N-OH MDMA in the samples could be precisely analyzed by avoiding an alkaline environment. The parent compound very rapidly disappeared from the rat plasma (<15 min) and urine (<10 h), and most of the N-OH MDMA was excreted in the rat urine as MDMA and MDA in 72 h. In the rat hair samples collected 4 weeks after the first administration, N-OH MDMA (0.03 ng/mg) and N-OH MDA (0.13 ng/mg) were clearly detected as well as MDMA (149 ng/mg) and MDA (52 ng/mg). This analytical method will be useful for the analysis of N-OH MDMA and its metabolites in biological samples." @default.
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• W2005473956 date "2010-05-01" @default.
• W2005473956 modified "2023-10-15" @default.
• W2005473956 title "Determination of a new designer drug, N-hydroxy-3,4-methylenedioxymethamphetamine and its metabolites in rats using ultra-performance liquid chromatography–tandem mass spectrometry" @default.
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• W2005473956 doi "https://doi.org/10.1016/j.forsciint.2010.02.013" @default.
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