FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005474407> ?p ?o ?g. }

• W2005474407 abstract "The effect of flupirtine on the loss of retinal ganglion cells following transient elevation of intraocular pressure (experimental ischaemia) or NMDA-induced excitotoxicity was studied. Ischaemia (60 min) or intravitreal injection of NMDA (20 nmol) caused a decrease in Thy-1 mRNA and Thy-1 immunoreactivity which are associated with ganglion cells. Administration of flupirtine counteracted these changes. Moreover, flupirtine dose-dependently inhibited NMDA-induced 45Ca(2+) influx into cultured cortical neurones and retinal pieces in vitro with maximal inhibition being observed at 200 microM. A similar concentration of flupirtine failed to inhibit kainate-stimulated calcium influx into cultured cortical neurones. In addition, flupirtine had no significant effect on [3H]nitrendipine or [3H]diltiazem binding to cortical membranes. The present studies are consistent with previous findings which suggested flupirtine to act as a NMDA antagonist by a mechanism that still remains to be clarified." @default.
• W2005474407 created "2016-06-24" @default.
• W2005474407 creator A5009309290 @default.
• W2005474407 creator A5014991981 @default.
• W2005474407 creator A5048134789 @default.
• W2005474407 creator A5069352403 @default.
• W2005474407 date "2000-02-01" @default.
• W2005474407 modified "2023-09-26" @default.
• W2005474407 title "Flupirtine ameliorates ischaemic-like death of rat retinal ganglion cells by preventing calcium influx" @default.
• W2005474407 cites W1581878917 @default.
• W2005474407 cites W1973336785 @default.
• W2005474407 cites W2001649286 @default.
• W2005474407 cites W2002155560 @default.
• W2005474407 cites W2003189878 @default.
• W2005474407 cites W2006904109 @default.
• W2005474407 cites W2013547432 @default.
• W2005474407 cites W2031017946 @default.
• W2005474407 cites W2039033026 @default.
• W2005474407 cites W2049811908 @default.
• W2005474407 cites W2052483410 @default.
• W2005474407 cites W2077441886 @default.
• W2005474407 cites W2079456047 @default.
• W2005474407 cites W2086662008 @default.
• W2005474407 cites W2087516355 @default.
• W2005474407 cites W2099151597 @default.
• W2005474407 cites W2116453034 @default.
• W2005474407 cites W247990163 @default.
• W2005474407 cites W2152426226 @default.
• W2005474407 doi "https://doi.org/10.1016/s0006-8993(99)02278-7" @default.
• W2005474407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10677631" @default.
• W2005474407 hasPublicationYear "2000" @default.
• W2005474407 type Work @default.
• W2005474407 sameAs 2005474407 @default.
• W2005474407 citedByCount "16" @default.
• W2005474407 countsByYear W20054744072015 @default.
• W2005474407 crossrefType "journal-article" @default.
• W2005474407 hasAuthorship W2005474407A5009309290 @default.
• W2005474407 hasAuthorship W2005474407A5014991981 @default.
• W2005474407 hasAuthorship W2005474407A5048134789 @default.
• W2005474407 hasAuthorship W2005474407A5069352403 @default.
• W2005474407 hasConcept C126322002 @default.
• W2005474407 hasConcept C160268369 @default.
• W2005474407 hasConcept C169760540 @default.
• W2005474407 hasConcept C170493617 @default.
• W2005474407 hasConcept C178790620 @default.
• W2005474407 hasConcept C185592680 @default.
• W2005474407 hasConcept C189184402 @default.
• W2005474407 hasConcept C2776885963 @default.
• W2005474407 hasConcept C2777093970 @default.
• W2005474407 hasConcept C2780548744 @default.
• W2005474407 hasConcept C2780827179 @default.
• W2005474407 hasConcept C2781012912 @default.
• W2005474407 hasConcept C519063684 @default.
• W2005474407 hasConcept C541997718 @default.
• W2005474407 hasConcept C55493867 @default.
• W2005474407 hasConcept C67018056 @default.
• W2005474407 hasConcept C71924100 @default.
• W2005474407 hasConcept C86803240 @default.
• W2005474407 hasConcept C98274493 @default.
• W2005474407 hasConceptScore W2005474407C126322002 @default.
• W2005474407 hasConceptScore W2005474407C160268369 @default.
• W2005474407 hasConceptScore W2005474407C169760540 @default.
• W2005474407 hasConceptScore W2005474407C170493617 @default.
• W2005474407 hasConceptScore W2005474407C178790620 @default.
• W2005474407 hasConceptScore W2005474407C185592680 @default.
• W2005474407 hasConceptScore W2005474407C189184402 @default.
• W2005474407 hasConceptScore W2005474407C2776885963 @default.
• W2005474407 hasConceptScore W2005474407C2777093970 @default.
• W2005474407 hasConceptScore W2005474407C2780548744 @default.
• W2005474407 hasConceptScore W2005474407C2780827179 @default.
• W2005474407 hasConceptScore W2005474407C2781012912 @default.
• W2005474407 hasConceptScore W2005474407C519063684 @default.
• W2005474407 hasConceptScore W2005474407C541997718 @default.
• W2005474407 hasConceptScore W2005474407C55493867 @default.
• W2005474407 hasConceptScore W2005474407C67018056 @default.
• W2005474407 hasConceptScore W2005474407C71924100 @default.
• W2005474407 hasConceptScore W2005474407C86803240 @default.
• W2005474407 hasConceptScore W2005474407C98274493 @default.
• W2005474407 hasLocation W20054744071 @default.
• W2005474407 hasLocation W20054744072 @default.
• W2005474407 hasOpenAccess W2005474407 @default.
• W2005474407 hasPrimaryLocation W20054744071 @default.
• W2005474407 hasRelatedWork W1553527908 @default.
• W2005474407 hasRelatedWork W1596952637 @default.
• W2005474407 hasRelatedWork W183906981 @default.
• W2005474407 hasRelatedWork W1963492300 @default.
• W2005474407 hasRelatedWork W1969811289 @default.
• W2005474407 hasRelatedWork W1984401984 @default.
• W2005474407 hasRelatedWork W2000549923 @default.
• W2005474407 hasRelatedWork W2042632071 @default.
• W2005474407 hasRelatedWork W2044762414 @default.
• W2005474407 hasRelatedWork W2059721998 @default.
• W2005474407 hasRelatedWork W2063063805 @default.
• W2005474407 hasRelatedWork W2065636160 @default.
• W2005474407 hasRelatedWork W2083346951 @default.
• W2005474407 hasRelatedWork W2087837001 @default.
• W2005474407 hasRelatedWork W2099151597 @default.
• W2005474407 hasRelatedWork W2101816383 @default.
• W2005474407 hasRelatedWork W2122477596 @default.
• W2005474407 hasRelatedWork W2271932147 @default.

• next