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- W2005474554 abstract "In many experimental tumor systems, small numbers of cancer cells can grow to kill the host animal. Cure demands the erradication of all cancer cells. Surgery and radiotherapy effectively eliminate the gross primary tumor masses; the major curative limitations for these modalities mainly are anatomical and/or the technical skills of the therapist. The number and size of micrometastatic foci located in vital visceral organs eventually will limit the success when only local therapy is used. Application of tumoricidal systemic treatments is an absolute necessity to achieve total cure, since these metastatic foci, if left untreated, eventually will kill the host. Based on experimental data Schabel recently has restated the cardinal principles of effective treatment for these micrometastases.*’ Briefly, they are: (1) When the primary tumor becomes visible, micrometastatic foci already are present. (2) The response of the clinically apparent tumors to chemotherapy may not predict from the sensitivity of the micrometastases. (3) The combination of local effective therapy and systemic treatment often produces cure even when neither modality alone can erradicate the cancer cells. How can we apply these principles to human breast cancer? The translation of these experimental approaches to the clinic requires a consideration of the systemic modalities which currently are avaiiable in breast cancer treatment and the development of new strategies based on knowledge of the biology of human breast cancer. This report is not intended to be an exhaustive review, but a selective presentation to illustrate certain principles of systemic treatment methods, to review important new data and to state what the future problems may be." @default.
- W2005474554 created "2016-06-24" @default.
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- W2005474554 date "1976-07-01" @default.
- W2005474554 modified "2023-09-27" @default.
- W2005474554 title "Systemic treatment of breast cancer: Past, present and future" @default.
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- W2005474554 doi "https://doi.org/10.1016/0360-3016(76)90164-4" @default.
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