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- W2005478435 abstract "The rates of DNA alkylation were established for the reaction of (+)-duocarmycin SA (1) with the native duplex d(G(1)TCAATTAGTC(11))*d(G(12)ACTAATTGAC(22)), an 11 bp deoxyoligonucleotide that contains a single high-affinity alkylation site that has been structurally characterized at exquisite resolution, and modified duplexes in which the four backbone phosphates proximal to the C4 carbonyl of bound 1 were replaced with methylphosphonates. All were found to react at comparable rates establishing that these backbone phosphates do not participate in catalysis of the DNA alkylation reaction." @default.
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- W2005478435 date "2002-02-01" @default.
- W2005478435 modified "2023-10-10" @default.
- W2005478435 title "The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction" @default.
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- W2005478435 doi "https://doi.org/10.1016/s0960-894x(01)00740-5" @default.
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