Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005481723> ?p ?o ?g. }
- W2005481723 endingPage "1868" @default.
- W2005481723 startingPage "1862" @default.
- W2005481723 abstract "ZC3H12A is a gene whose absence is related to autoimmune disorders and to other phenotypical alterations. A comprehensive review of the structure, molecular functions and regulation of ZC3H12A gene and its protein MCPIP1 is done in order to understand their clinical implications. ZC3H12A, at 1p34.3, has 9860 bp, six exons and 61 described SNPs. Eleven are non-synonymous thus leading to changes in MCPIP1, the protein encoded by ZC3H12A. MCPIP1 is induced by MCP-1 and IL-1 whose signals are transduced through the NF-kβ and MAPkinase pathways. This protein acts as an RNAse by degrading chemokine transcripts such as IL-1 as well as its own mRNA and as a transcription factor by reducing the expression of other chemokines induced by NF-kβ such as MCP-1. It also up-regulates genes involved in several differentiation processes and apoptosis. Therefore, ZC3H12A is an equilibrium gatekeeper that not only regulates its own inducers but also controls the regulation by degrading its own mRNA. Understanding ZC3H12A gives a comprehensive panorama that promises to improve our understanding of processes in which this gene is involved including autoimmune, infectious and cardiovascular diseases." @default.
- W2005481723 created "2016-06-24" @default.
- W2005481723 creator A5051051572 @default.
- W2005481723 creator A5059753375 @default.
- W2005481723 creator A5064761777 @default.
- W2005481723 creator A5083119450 @default.
- W2005481723 date "2010-12-01" @default.
- W2005481723 modified "2023-09-26" @default.
- W2005481723 title "ZC3H12A (MCPIP1): Molecular characteristics and clinical implications" @default.
- W2005481723 cites W1502493645 @default.
- W2005481723 cites W1524369431 @default.
- W2005481723 cites W1541180915 @default.
- W2005481723 cites W1562963428 @default.
- W2005481723 cites W1965323386 @default.
- W2005481723 cites W1966428624 @default.
- W2005481723 cites W1970632381 @default.
- W2005481723 cites W1988079322 @default.
- W2005481723 cites W1989215685 @default.
- W2005481723 cites W1992319286 @default.
- W2005481723 cites W1992619779 @default.
- W2005481723 cites W2003409252 @default.
- W2005481723 cites W2004812549 @default.
- W2005481723 cites W2017160090 @default.
- W2005481723 cites W2032514883 @default.
- W2005481723 cites W2034880481 @default.
- W2005481723 cites W2035250595 @default.
- W2005481723 cites W2036429261 @default.
- W2005481723 cites W2037072555 @default.
- W2005481723 cites W2039229911 @default.
- W2005481723 cites W2051235714 @default.
- W2005481723 cites W2052534171 @default.
- W2005481723 cites W2055317878 @default.
- W2005481723 cites W2060761598 @default.
- W2005481723 cites W2065624229 @default.
- W2005481723 cites W2067172877 @default.
- W2005481723 cites W2067667993 @default.
- W2005481723 cites W2080039364 @default.
- W2005481723 cites W2085671871 @default.
- W2005481723 cites W2086827933 @default.
- W2005481723 cites W2088842969 @default.
- W2005481723 cites W2089015359 @default.
- W2005481723 cites W2089918897 @default.
- W2005481723 cites W2094027122 @default.
- W2005481723 cites W2094399673 @default.
- W2005481723 cites W2099873826 @default.
- W2005481723 cites W2103195473 @default.
- W2005481723 cites W2103591331 @default.
- W2005481723 cites W2104513101 @default.
- W2005481723 cites W2108453561 @default.
- W2005481723 cites W2116265508 @default.
- W2005481723 cites W2130329649 @default.
- W2005481723 cites W2133792952 @default.
- W2005481723 cites W2138966960 @default.
- W2005481723 cites W2141342239 @default.
- W2005481723 cites W2144085720 @default.
- W2005481723 cites W2146840987 @default.
- W2005481723 cites W2146917818 @default.
- W2005481723 cites W2153816748 @default.
- W2005481723 cites W2165984084 @default.
- W2005481723 cites W2166582643 @default.
- W2005481723 cites W2169211336 @default.
- W2005481723 cites W2170588662 @default.
- W2005481723 cites W2170659903 @default.
- W2005481723 doi "https://doi.org/10.1016/j.cca.2010.08.033" @default.
- W2005481723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20807520" @default.
- W2005481723 hasPublicationYear "2010" @default.
- W2005481723 type Work @default.
- W2005481723 sameAs 2005481723 @default.
- W2005481723 citedByCount "16" @default.
- W2005481723 countsByYear W20054817232012 @default.
- W2005481723 countsByYear W20054817232013 @default.
- W2005481723 countsByYear W20054817232014 @default.
- W2005481723 countsByYear W20054817232015 @default.
- W2005481723 countsByYear W20054817232016 @default.
- W2005481723 countsByYear W20054817232017 @default.
- W2005481723 countsByYear W20054817232018 @default.
- W2005481723 countsByYear W20054817232019 @default.
- W2005481723 countsByYear W20054817232020 @default.
- W2005481723 countsByYear W20054817232021 @default.
- W2005481723 crossrefType "journal-article" @default.
- W2005481723 hasAuthorship W2005481723A5051051572 @default.
- W2005481723 hasAuthorship W2005481723A5059753375 @default.
- W2005481723 hasAuthorship W2005481723A5064761777 @default.
- W2005481723 hasAuthorship W2005481723A5083119450 @default.
- W2005481723 hasConcept C104317684 @default.
- W2005481723 hasConcept C105580179 @default.
- W2005481723 hasConcept C10879258 @default.
- W2005481723 hasConcept C127716648 @default.
- W2005481723 hasConcept C12823836 @default.
- W2005481723 hasConcept C13373296 @default.
- W2005481723 hasConcept C150194340 @default.
- W2005481723 hasConcept C203014093 @default.
- W2005481723 hasConcept C2775866117 @default.
- W2005481723 hasConcept C2776914184 @default.
- W2005481723 hasConcept C36823959 @default.
- W2005481723 hasConcept C54355233 @default.
- W2005481723 hasConcept C54458228 @default.
- W2005481723 hasConcept C67705224 @default.