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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005482308> ?p ?o ?g. }

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• W2005482308 startingPage "5021" @default.
• W2005482308 abstract "Metabolic oligosaccharide engineering is a powerful approach for installing unnatural glycans with unique functional groups into the glycocalyx of living cells and animals. Using this approach, we showed that K+ channel complexes decorated with thiol-containing sialic acids were irreversibly inhibited with scorpion toxins bearing a pendant maleimide group. Irreversible inhibition required a glycosylated K+ channel subunit and was completely reversible with mild reductant when the tether connecting the toxin to the maleimide contained a disulfide bond. Cleavage of the disulfide bond not only restored function, but delivered a biotin moiety to the modified K+ channel subunit, providing a novel approach for preferentially labeling wild type K+ channel complexes functioning in cells." @default.
• W2005482308 created "2016-06-24" @default.
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• W2005482308 date "2011-09-01" @default.
• W2005482308 modified "2023-09-30" @default.
• W2005482308 title "Chemical control of metabolically-engineered voltage-gated K+ channels" @default.
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• W2005482308 doi "https://doi.org/10.1016/j.bmcl.2011.04.099" @default.
• W2005482308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3156388" @default.
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