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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005484150> ?p ?o ?g. }

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• W2005484150 abstract "Glioblastoma (GBM) is a highly infiltrating, aggressive brain cancer with no available curative treatment. We developed a rapid assay for assessing the effect of various drugs on GBM stem cells. The assay uses a small number of separated CD133+ cells (20,000 in 0.2 ml) in 96-well plate that form neurospheres within 1–2 days. Various drugs disperse the neurospheres within 24–36 h, which can be quantified microscopically. We used the GBM cell line A-172 to develop the conditions for the assay, utilizing Gleevec, the gamma-secretase inhibitor DAPT, and the anti-bacterial peptide amph1D. The results show dispersion of the neurospheres leading to cell death, at relatively low drugs concentrations (<25 μM). Drug combination showed a synergistic effect and disruption of neurospheres under lower concentrations. We applied this assay to the CD133+ cells of surgical specimens from three patients that showed similar results. This assay facilitates a rapid test of drugs on small amounts of fractionated patient’s GBM stem cells." @default.
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• W2005484150 date "2007-07-01" @default.
• W2005484150 modified "2023-10-15" @default.
• W2005484150 title "A rapid assay for drug sensitivity of glioblastoma stem cells" @default.
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• W2005484150 doi "https://doi.org/10.1016/j.bbrc.2007.05.020" @default.
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