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- W2005485612 abstract "<b>Objective:</b> The purpose of this study was to compare prostaglandin E<sub>2</sub> gel and a low-dose infusion of oxytocin for cervical ripening before labor induction. <b>Study Design:</b> A total of 158 women were randomized to receive either two intracervical doses of 0.5 mg prostaglandin E<sub>2</sub> gel 6 hours apart or 12 hours of intravenous oxytocin up to 4 mlU/min. After cervical ripening labor was induced with high-dose oxytocin infusion and amniotomy. <b>Results:</b> There was no difference between the prostaglandin E<sub>2</sub> and low-dose oxytocin groups in the likelihood of being in labor or having a Bishop score favorable for induction after ripening (64.2% vs 52.0%, <i>p</i> = 0.12) or in the incidence of vaginal delivery (75.9% vs 74.7%). Progstaglandin E<sub>2</sub> treated patients were delivered sooner (20.2 ± 8.1 hours vs 25.0 ± 10.5 hours, <i>p</i> = 0.002). Among delivered patients the likelihood of vaginal delivery within 24 hours was greater with prostaglandin E<sub>2</sub> ripening (63.7% vs 47.2%, <i>p</i> = 0.04), but there was no difference at 36 hours (76.2% vs 75.0%). Uterine hyperstimulation and fetal distress during ripening occurred only in the prostaglandin E<sub>2</sub> group, at a rate of 4.8%. <b>Conclusions:</b> After cervical ripening with prostaglandin E<sub>2</sub> gel or low-dose oxytocin vaginal delivery can be expected in three fourths of patients within 24 to 36 hours. We recommend that patients with an unfavorable cervix who require delivery undergo cervical ripening and induction of labor rather than automatic delivery by cesarean section." @default.
- W2005485612 created "2016-06-24" @default.
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- W2005485612 date "1994-10-01" @default.
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- W2005485612 title "Cervical ripening before induction of labor: A randomized trial of prostaglandin E2gel versus low-dose oxytocin" @default.
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- W2005485612 doi "https://doi.org/10.1016/0002-9378(94)90042-6" @default.
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