FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005486632> ?p ?o ?g. }

• W2005486632 endingPage "262" @default.
• W2005486632 startingPage "257" @default.
• W2005486632 abstract "An objective was to determine the frequency of GM-CSF secreting peripheral blood mononuclear cells (PBMC) in patients with active systemic lupus erythematosus (SLE) and their relation to other cytokine secreting PBMC, activation markers on lymphocytes/monocytes, clinical manifestations and anti- dsDNA antibodies.A second objectivewas to further investigatethe influence of immunoadsorption(IA) therapy on these parameters.The number of GM-CSF, interleukin-1b (IL-1b), IL-6, interferon-g (INF-g) or tumour necrosis factor-a (TNF-a) secreting PBMC was assessed by ELISPOT assay in 10 patients with active SLE. Further, the expression of activation markers on lymphocytes and monocytes was determined by flow cytometry. Three courses of IA were performed in the patients. Seventeen healthy, age- and sex-matched volunteers served as controls. GM-CSF secreting PBMC were significantly increased whereas INF-g secreting cells were decreased in SLE patients. The expression of CD71 (transferrin receptor) on CD4 + T-cells and of the costimulatorymolecule CD86 on B-lymphocyteswas significantly increased in SLE patients. GM-CSF secreting PBMC and CD4 + /CD71 + T-cells correlated with anti-dsDNA antibody titres and decreased towards levels of controls during IA. Disease activity and anti-dsDNA autoantibody titres were significantly reduced after the treatment. Our results demonstrate significant alterations of cellular and humoral immunity in SLE patients. The impaired immunity can be modulated by IA. Thus IA may prove an immunomodulatory therapeutic option in addition to the mere depletion of anti-dsDNA autoantibodies." @default.
• W2005486632 created "2016-06-24" @default.
• W2005486632 creator A5030160890 @default.
• W2005486632 creator A5033193879 @default.
• W2005486632 creator A5037057775 @default.
• W2005486632 creator A5063217477 @default.
• W2005486632 creator A5067841113 @default.
• W2005486632 creator A5081872257 @default.
• W2005486632 creator A5082302773 @default.
• W2005486632 date "2004-04-01" @default.
• W2005486632 modified "2023-09-26" @default.
• W2005486632 title "Increased frequency of GM-CSF secreting PBMC in patients with active systemic lupus erythematosus can be reduced by immunoadsorption" @default.
• W2005486632 cites W1037044114 @default.
• W2005486632 cites W1965683411 @default.
• W2005486632 cites W1974245886 @default.
• W2005486632 cites W1982641899 @default.
• W2005486632 cites W1988321863 @default.
• W2005486632 cites W1994533352 @default.
• W2005486632 cites W1995029669 @default.
• W2005486632 cites W2001373821 @default.
• W2005486632 cites W2021317800 @default.
• W2005486632 cites W2022303626 @default.
• W2005486632 cites W2023387239 @default.
• W2005486632 cites W2055071429 @default.
• W2005486632 cites W2055814218 @default.
• W2005486632 cites W2062450447 @default.
• W2005486632 cites W2072246224 @default.
• W2005486632 cites W2075450457 @default.
• W2005486632 cites W2092772734 @default.
• W2005486632 cites W2118781231 @default.
• W2005486632 cites W2123337850 @default.
• W2005486632 cites W2133340337 @default.
• W2005486632 cites W2146203649 @default.
• W2005486632 cites W2149647255 @default.
• W2005486632 cites W2164979183 @default.
• W2005486632 cites W2171803224 @default.
• W2005486632 cites W4313342352 @default.
• W2005486632 doi "https://doi.org/10.1191/0961203304lu1009oa" @default.
• W2005486632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15176662" @default.
• W2005486632 hasPublicationYear "2004" @default.
• W2005486632 type Work @default.
• W2005486632 sameAs 2005486632 @default.
• W2005486632 citedByCount "27" @default.
• W2005486632 countsByYear W20054866322012 @default.
• W2005486632 countsByYear W20054866322013 @default.
• W2005486632 countsByYear W20054866322014 @default.
• W2005486632 countsByYear W20054866322015 @default.
• W2005486632 countsByYear W20054866322016 @default.
• W2005486632 countsByYear W20054866322018 @default.
• W2005486632 countsByYear W20054866322019 @default.
• W2005486632 countsByYear W20054866322020 @default.
• W2005486632 countsByYear W20054866322021 @default.
• W2005486632 countsByYear W20054866322023 @default.
• W2005486632 crossrefType "journal-article" @default.
• W2005486632 hasAuthorship W2005486632A5030160890 @default.
• W2005486632 hasAuthorship W2005486632A5033193879 @default.
• W2005486632 hasAuthorship W2005486632A5037057775 @default.
• W2005486632 hasAuthorship W2005486632A5063217477 @default.
• W2005486632 hasAuthorship W2005486632A5067841113 @default.
• W2005486632 hasAuthorship W2005486632A5081872257 @default.
• W2005486632 hasAuthorship W2005486632A5082302773 @default.
• W2005486632 hasConcept C137061746 @default.
• W2005486632 hasConcept C159654299 @default.
• W2005486632 hasConcept C163764329 @default.
• W2005486632 hasConcept C202751555 @default.
• W2005486632 hasConcept C203014093 @default.
• W2005486632 hasConcept C2776090121 @default.
• W2005486632 hasConcept C2778690821 @default.
• W2005486632 hasConcept C2779053233 @default.
• W2005486632 hasConcept C2779839709 @default.
• W2005486632 hasConcept C55493867 @default.
• W2005486632 hasConcept C71924100 @default.
• W2005486632 hasConcept C86803240 @default.
• W2005486632 hasConcept C8891405 @default.
• W2005486632 hasConceptScore W2005486632C137061746 @default.
• W2005486632 hasConceptScore W2005486632C159654299 @default.
• W2005486632 hasConceptScore W2005486632C163764329 @default.
• W2005486632 hasConceptScore W2005486632C202751555 @default.
• W2005486632 hasConceptScore W2005486632C203014093 @default.
• W2005486632 hasConceptScore W2005486632C2776090121 @default.
• W2005486632 hasConceptScore W2005486632C2778690821 @default.
• W2005486632 hasConceptScore W2005486632C2779053233 @default.
• W2005486632 hasConceptScore W2005486632C2779839709 @default.
• W2005486632 hasConceptScore W2005486632C55493867 @default.
• W2005486632 hasConceptScore W2005486632C71924100 @default.
• W2005486632 hasConceptScore W2005486632C86803240 @default.
• W2005486632 hasConceptScore W2005486632C8891405 @default.
• W2005486632 hasIssue "4" @default.
• W2005486632 hasLocation W20054866321 @default.
• W2005486632 hasLocation W20054866322 @default.
• W2005486632 hasOpenAccess W2005486632 @default.
• W2005486632 hasPrimaryLocation W20054866321 @default.
• W2005486632 hasRelatedWork W1988182648 @default.
• W2005486632 hasRelatedWork W2047209980 @default.
• W2005486632 hasRelatedWork W2087976276 @default.
• W2005486632 hasRelatedWork W2101875571 @default.
• W2005486632 hasRelatedWork W2166157026 @default.
• W2005486632 hasRelatedWork W2317914672 @default.

• next