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- W2005486831 abstract "Opioid receptors have been demonstrated by light microscopic techniques in fine cutaneous nerves in naive animals. The present study extends these findings by showing that 29 and 38% of unmyelinated cutaneous sensory axons can be immunostained for μ- or δ-opioid receptors respectively. Local cutaneous injection of DAMGO, a μ-opioid ligand, ameliorates the nociceptive behaviors caused by local cutaneous injection of glutamate, a purely nociceptive chemical stimulus showing that the μ-receptors are functional. By contrast the δ-opioid ligand [2-d-penicillamine, 5-d-penicillamine]enkephalin (DPDPE) had no effect on these behaviors. These findings indicate a wider function for opioid receptors in naive animals than previously envisioned." @default.
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- W2005486831 date "1997-08-01" @default.
- W2005486831 modified "2023-10-14" @default.
- W2005486831 title "Opioid receptors on peripheral sensory axons" @default.
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- W2005486831 doi "https://doi.org/10.1016/s0006-8993(97)00446-0" @default.
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