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• W2005487617 abstract "Liver transplantation appears to be quite beneficial for treatment of maple syrup urine disease (MSUD, an inherited disorder of branched chain amino acid metabolism); however, there is a limited availability of donor livers worldwide and the first year costs of liver transplants are quite high. Recent studies have suggested that intact adipose tissue, already widely used in reconstructive surgery, may have an underappreciated high capacity for branched chain amino acid (BCAA) metabolism. Here we examined the potential for adipose tissue transplant to lower circulating BCAAs in two models of defective BCAA metabolism, BCATm and PP2Cm [branched chain keto acid dehydrogenase complex (BCKDC) phosphatase] knockout (KO) mice. After 1–2 g fat transplant, BCATm and PP2Cm KO mice gained or maintained body weight 3 weeks after surgery and consumed similar or more food/BCAAs the week before phlebotomy. Transplant of fat into the abdominal cavity led to a sterile inflammatory response and nonviable transplanted tissue. However when 1–2 g of fat was transplanted subcutaneously into the back, either as small (0.1–0.3 g) or finely minced pieces introduced with an 18-ga. needle, plasma BCAAs decreased compared to Sham operated mice. In two studies on BCATm KO mice and one study on PP2Cm KO mice, fat transplant led to 52–81% reductions in plasma BCAAs compared to baseline plasma BCAA concentrations of untreated WT type siblings. In PP2Cm KO mice, individual BCAAs in plasma were also significantly reduced by fat transplant, as were the alloisoleucine/Phe ratios. Therefore, subcutaneous fat transplantation may have merit as an adjunct to dietary treatment of MSUD. Additional studies are needed to further refine this approach." @default.
• W2005487617 created "2016-06-24" @default.
• W2005487617 creator A5019906052 @default.
• W2005487617 creator A5042437739 @default.
• W2005487617 creator A5064095780 @default.
• W2005487617 creator A5091691353 @default.
• W2005487617 date "2013-08-01" @default.
• W2005487617 modified "2023-10-10" @default.
• W2005487617 title "Adipose transplant for inborn errors of branched chain amino acid metabolism in mice" @default.
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• W2005487617 cites W1921797022 @default.
• W2005487617 cites W1953493409 @default.
• W2005487617 cites W1963077573 @default.
• W2005487617 cites W1967898940 @default.
• W2005487617 cites W1968963111 @default.
• W2005487617 cites W1969911818 @default.
• W2005487617 cites W1971360406 @default.
• W2005487617 cites W1971673889 @default.
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• W2005487617 cites W1978072893 @default.
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• W2005487617 cites W1989798945 @default.
• W2005487617 cites W2007272066 @default.
• W2005487617 cites W2008839419 @default.
• W2005487617 cites W2012377009 @default.
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• W2005487617 cites W2024243106 @default.
• W2005487617 cites W2024245010 @default.
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• W2005487617 cites W2028967877 @default.
• W2005487617 cites W2036140394 @default.
• W2005487617 cites W2044146361 @default.
• W2005487617 cites W2044544963 @default.
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• W2005487617 cites W2049374892 @default.
• W2005487617 cites W2050628265 @default.
• W2005487617 cites W2050980384 @default.
• W2005487617 cites W2057552993 @default.
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• W2005487617 cites W2088993157 @default.
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• W2005487617 cites W2168533782 @default.
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• W2005487617 doi "https://doi.org/10.1016/j.ymgme.2013.05.010" @default.
• W2005487617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3955948" @default.
• W2005487617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23800641" @default.
• W2005487617 hasPublicationYear "2013" @default.
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