FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005487987> ?p ?o ?g. }

• W2005487987 endingPage "e54336" @default.
• W2005487987 startingPage "e54336" @default.
• W2005487987 abstract "Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely contribute to the highly dynamic processes at the implantation site. The present study was undertaken to further characterize the mechanisms involved in the regulation of endometrial stromal cell motility and to identify trophoblast-derived factors that modulate migration. Among local growth factors known to be present at the time of implantation, heparin-binding epidermal growth factor-like growth factor (HB-EGF) triggered chemotaxis (directed locomotion), whereas platelet-derived growth factor (PDGF)-BB elicited both chemotaxis and chemokinesis (non-directed locomotion) of endometrial stromal cells. Supernatants of the trophoblast cell line AC-1M88 and of first trimester villous explant cultures stimulated chemotaxis but not chemokinesis. Proteome profiling for cytokines and angiogenesis factors revealed neither PDGF-BB nor HB-EGF in conditioned media from trophoblast cells or villous explants, while placental growth factor, vascular endothelial growth factor and PDGF-AA were identified as prominent secretory products. Among these, only PDGF-AA triggered endometrial stromal cell chemotaxis. Neutralization of PDGF-AA in trophoblast conditioned media, however, did not diminish chemoattractant activity, suggesting the presence of additional trophoblast-derived chemotactic factors. Pathway inhibitor studies revealed ERK1/2, PI3 kinase/Akt and p38 signaling as relevant for chemotactic motility, whereas chemokinesis depended primarily on PI3 kinase/Akt activation. Both chemotaxis and chemokinesis were stimulated upon inhibition of Rho-associated, coiled-coil containing protein kinase. The chemotactic response to trophoblast secretions was not blunted by inhibition of isolated signaling cascades, indicating activation of overlapping pathways in trophoblast-endometrial communication. In conclusion, trophoblast signals attract endometrial stromal cells, while PDGF-BB and HB-EGF, although not identified as trophoblast-derived, are local growth factors that may serve to fine-tune directed and non-directed migration at the implantation site." @default.
• W2005487987 created "2016-06-24" @default.
• W2005487987 creator A5017106218 @default.
• W2005487987 creator A5020628846 @default.
• W2005487987 creator A5028455936 @default.
• W2005487987 creator A5061795013 @default.
• W2005487987 creator A5064678774 @default.
• W2005487987 creator A5066339882 @default.
• W2005487987 creator A5079813676 @default.
• W2005487987 creator A5084135499 @default.
• W2005487987 creator A5084668010 @default.
• W2005487987 creator A5091306061 @default.
• W2005487987 date "2013-01-21" @default.
• W2005487987 modified "2023-10-17" @default.
• W2005487987 title "Control of Human Endometrial Stromal Cell Motility by PDGF-BB, HB-EGF and Trophoblast-Secreted Factors" @default.
• W2005487987 cites W1969753756 @default.
• W2005487987 cites W1970089611 @default.
• W2005487987 cites W1972766975 @default.
• W2005487987 cites W1974456378 @default.
• W2005487987 cites W1976298275 @default.
• W2005487987 cites W1976905678 @default.
• W2005487987 cites W1977381126 @default.
• W2005487987 cites W1984918145 @default.
• W2005487987 cites W1986469266 @default.
• W2005487987 cites W1989943377 @default.
• W2005487987 cites W1991463546 @default.
• W2005487987 cites W1993866784 @default.
• W2005487987 cites W2003801328 @default.
• W2005487987 cites W2003885969 @default.
• W2005487987 cites W2013642882 @default.
• W2005487987 cites W2015679500 @default.
• W2005487987 cites W2023144895 @default.
• W2005487987 cites W2028496807 @default.
• W2005487987 cites W2042373581 @default.
• W2005487987 cites W2044895919 @default.
• W2005487987 cites W2045461902 @default.
• W2005487987 cites W2046387677 @default.
• W2005487987 cites W2049014099 @default.
• W2005487987 cites W2049230776 @default.
• W2005487987 cites W2053701919 @default.
• W2005487987 cites W2055035644 @default.
• W2005487987 cites W2063196567 @default.
• W2005487987 cites W2065346340 @default.
• W2005487987 cites W2066873624 @default.
• W2005487987 cites W2075091190 @default.
• W2005487987 cites W2081211027 @default.
• W2005487987 cites W2082276924 @default.
• W2005487987 cites W2082637668 @default.
• W2005487987 cites W2082651352 @default.
• W2005487987 cites W2084232786 @default.
• W2005487987 cites W2084990460 @default.
• W2005487987 cites W2085996922 @default.
• W2005487987 cites W2092182760 @default.
• W2005487987 cites W2092592525 @default.
• W2005487987 cites W2094540897 @default.
• W2005487987 cites W2096282446 @default.
• W2005487987 cites W2100488321 @default.
• W2005487987 cites W2100963977 @default.
• W2005487987 cites W2101519077 @default.
• W2005487987 cites W2103549320 @default.
• W2005487987 cites W2105837861 @default.
• W2005487987 cites W2105944754 @default.
• W2005487987 cites W2108994898 @default.
• W2005487987 cites W2112668385 @default.
• W2005487987 cites W2112675387 @default.
• W2005487987 cites W2114152707 @default.
• W2005487987 cites W2114982081 @default.
• W2005487987 cites W2115523693 @default.
• W2005487987 cites W2120403739 @default.
• W2005487987 cites W2127877233 @default.
• W2005487987 cites W2130639719 @default.
• W2005487987 cites W2135025368 @default.
• W2005487987 cites W2138743095 @default.
• W2005487987 cites W2143891754 @default.
• W2005487987 cites W2145444991 @default.
• W2005487987 cites W2151780324 @default.
• W2005487987 cites W2161682775 @default.
• W2005487987 cites W2163223977 @default.
• W2005487987 cites W2167950650 @default.
• W2005487987 cites W2168063892 @default.
• W2005487987 cites W2168910626 @default.
• W2005487987 cites W2169425267 @default.
• W2005487987 cites W2171391056 @default.
• W2005487987 cites W2171497320 @default.
• W2005487987 cites W4252553635 @default.
• W2005487987 doi "https://doi.org/10.1371/journal.pone.0054336" @default.
• W2005487987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3549986" @default.
• W2005487987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23349855" @default.
• W2005487987 hasPublicationYear "2013" @default.
• W2005487987 type Work @default.
• W2005487987 sameAs 2005487987 @default.
• W2005487987 citedByCount "50" @default.
• W2005487987 countsByYear W20054879872013 @default.
• W2005487987 countsByYear W20054879872014 @default.
• W2005487987 countsByYear W20054879872015 @default.
• W2005487987 countsByYear W20054879872016 @default.
• W2005487987 countsByYear W20054879872017 @default.
• W2005487987 countsByYear W20054879872018 @default.

• next