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- W2005491344 endingPage "e48482" @default.
- W2005491344 startingPage "e48482" @default.
- W2005491344 abstract "Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) and exposure to early childhood adversities (CA) are independently associated with individual differences in cognitive and emotional processing. Whether these two factors interact to influence cognitive and emotional processing is not known.We used a sample of 238 adolescents from a community study characterised by the presence of the short allele of 5-HTTLPR (LL, LS, SS) and the presence or absence of exposure to CA before 6 years of age. We measured cognitive and emotional processing using a set of neuropsychological tasks selected predominantly from the CANTAB® battery. We found that adolescents homozygous for the short allele (SS) of 5-HTTLPR and exposed to CA were worse at classifying negative and neutral stimuli and made more errors in response to ambiguous negative feedback. In addition, cognitive and emotional processing deficits were associated with diagnoses of anxiety and/or depressions.Cognitive and emotional processing deficits may act as a transdiagnostic intermediate marker for anxiety and depressive disorders in genetically susceptible individuals exposed to CA." @default.
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- W2005491344 date "2012-11-28" @default.
- W2005491344 modified "2023-10-17" @default.
- W2005491344 title "5-HTTLPR and Early Childhood Adversities Moderate Cognitive and Emotional Processing in Adolescence" @default.
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- W2005491344 doi "https://doi.org/10.1371/journal.pone.0048482" @default.
- W2005491344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3509124" @default.
- W2005491344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23209555" @default.