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- W2005491497 abstract "Abstract Purpose: The speed of onset of depressive episodes is a clinical aspect of affective disorders that has not been sufficiently investigated. Thus, we aimed to explore whether patients with fast onset of the full-blown depressive symptomatology (≤ 7 days) differ from those with slow onset (> 7 days) with regard to demographic and clinical aspects. Subjects and methods: Data were obtained within an observational study conducted in outpatients with major depression who were treated with duloxetine (30–120 mg/day). Onset of depression (without any preceding critical life event) was fast in 416 (less than one week) and slower in 2220 patients. Results: Compared to patients with slow onset, those with fast onset of depression had more suicide attempts in the previous 12 months (2.7% versus 1.3%, P = 0.046) and less somatic comorbidity (61.7% versus 74.1%, P < 0.0001). In addition, they were slightly younger at onset of depression (mean ± SD 40.2 ± 14.6 versus 42.8 ± 14.2 years, P < 0.001) and used analgesics at baseline significantly less frequently (22.8% versus 33.4%, P < 0.0001). Discussion and conclusion: The speed of onset of depression has to be regarded as a relevant clinical characteristic in patients with unipolar depression." @default.
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- W2005491497 date "2013-06-01" @default.
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- W2005491497 title "Fast versus slow onset of depressive episodes: A clinical criterion for subtyping patients with major depression" @default.
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- W2005491497 doi "https://doi.org/10.1016/j.eurpsy.2012.02.002" @default.
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