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• W2005493813 startingPage "613" @default.
• W2005493813 abstract "Over the past two years, there has been a spectacular change in the capacity to identify common genetic variants that contribute to predisposition to complex multifactorial phenotypes such as type 2 diabetes (T2D). The principal advance has been the ability to undertake surveys of genome-wide association in large study samples. Through these and related efforts, ∼20 common variants are now robustly implicated in T2D susceptibility. Current developments, for example in high-throughput resequencing, should help to provide a more comprehensive view of T2D susceptibility in the near future. Although additional investigation is needed to define the causal variants within these novel T2D-susceptibility regions, to understand disease mechanisms and to effect clinical translation, these findings are already highlighting the predominant contribution of defects in pancreatic β-cell function to the development of T2D. Over the past two years, there has been a spectacular change in the capacity to identify common genetic variants that contribute to predisposition to complex multifactorial phenotypes such as type 2 diabetes (T2D). The principal advance has been the ability to undertake surveys of genome-wide association in large study samples. Through these and related efforts, ∼20 common variants are now robustly implicated in T2D susceptibility. Current developments, for example in high-throughput resequencing, should help to provide a more comprehensive view of T2D susceptibility in the near future. Although additional investigation is needed to define the causal variants within these novel T2D-susceptibility regions, to understand disease mechanisms and to effect clinical translation, these findings are already highlighting the predominant contribution of defects in pancreatic β-cell function to the development of T2D." @default.
• W2005493813 created "2016-06-24" @default.
• W2005493813 creator A5010904149 @default.
• W2005493813 creator A5013273481 @default.
• W2005493813 creator A5048738826 @default.
• W2005493813 date "2008-12-01" @default.
• W2005493813 modified "2023-10-15" @default.
• W2005493813 title "Type 2 diabetes: new genes, new understanding" @default.
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• W2005493813 doi "https://doi.org/10.1016/j.tig.2008.09.004" @default.
• W2005493813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7116807" @default.
• W2005493813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18952314" @default.
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