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- W2005494054 abstract "A significant proportion of patients on proton pump inhibitors (PPI) reports insufficient control of symptoms, most probably resulting from ongoing reflux of non-acid and acid material. As reflux mainly occurs during transient lower esophageal sphincter relaxations (TLESRs), drugs targeting this motor pattern may be of great interest to further reduce symptoms. Baclofen, a GABA(B) receptor agonist, is the prototype of reflux inhibitors, reducing the number of TLESRs, reflux, and symptoms, but the central side effects are significant. Peripheral acting GABA(B) agonists hopefully devoid of these side effects are currently under study. Alternatively, antagonists to the metabotropic glutamate receptor 5 (mGluR5) reported to reduce TLESRs and reflux may be of interest. Upcoming clinical trials with these reflux inhibitors will hopefully answer the question whether reflux inhibitors are indeed a new approach to treat GERD." @default.
- W2005494054 created "2016-06-24" @default.
- W2005494054 creator A5051093942 @default.
- W2005494054 date "2008-12-01" @default.
- W2005494054 modified "2023-09-25" @default.
- W2005494054 title "Reflux inhibitors: a new approach for GERD?" @default.
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- W2005494054 doi "https://doi.org/10.1016/j.coph.2008.08.005" @default.
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