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• W2005495564 abstract "Streptococcus pneumoniae and Neisseria meningitidis are major causes of severe invasive bacterial infections in some individuals. Apparently the genetic is a major susceptibility determinant to these infectious diseases. We study if the functional polymorphisms within genes of the innate immune system (TLR2–TLR4 and CD14) are related to the predisposition to severe invasive infections caused by S. pneumoniae and N. meningitidis. Prospective descriptive study. Sixty-six Caucasian healthy children and 173 consecutive Caucasian children with invasive bacterial infections by N. meningitidis (n = 59) and S. pneumoniae (n = 114) were enrolled between January 1, 2008 and December 31, 2010. All blood samples were genotyped with description of the coding polymorphisms in p.R753Q of TLR2 gene and p.D299G of TLR4 gene as well as the promotor polymorphism c.-159C>T of the CD14 gene. Compared to the controls the p.753Q allele of TLR2 and the allele c.-159T of CD14 were more frequent in patients with S. pneumoniae (p < 0.0001 and p = 0.0167) and meningococcal infections (p = 0.0003 and p = 0.0276 respectively). Genetical variations in the innate immune system by polymorphisms in the TLR2 and CD14, could be related with an increases susceptibility to severe invasive infections by S. pneumoniae and N. meningitidis. Streptococcus pneumoniae y Neisseria meningitides son causantes de infección bacteriana grave en algunos individuos. Cierta susceptibilidad genética puede ser determinante para este hecho. Nuestro objetivo es determinar si el polimorfismo de genes relacionados con el sistema inmune innato (Toll like receptor 2 y 4 junto con CD14) se relaciona con la predisposición a sufrir infecciones graves por los citados patógenos. Estudio prospectivo observacional (desde el 1 de enero de 2008 hasta el 31 de diciembre de 2010). Se incluye a 66 niños sanos y 173 niños con infección bacteriana grave (59 por Neisseria meningitidis y 114 por Streptococcus pneumoniae). Todas las muestras fueron genotipadas para los polimorfismos p.R753Q de TLR2, p.D299G de TLR4 y c.–159C > T del CD14. Comparados con los controles, los polimorfismos p.753Q de TLR2 y c.–159C > T de CD14 fueron más frecuentes en pacientes con infección neumocócica (p < 0,0001 y p = 0,0167) y meningocócica (p = 0,0003 y p = 0,0276). Las variaciones genéticas en el sistema inmune innato mediante polimorfismos en TLR2 y CD14 podrían estar relacionadas con la susceptibilidad a las infecciones graves por Streptococcus pneumoniae y Neisseria meningitides." @default.
• W2005495564 created "2016-06-24" @default.
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• W2005495564 date "2014-08-01" @default.
• W2005495564 modified "2023-09-25" @default.
• W2005495564 title "TLR2–TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae" @default.
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• W2005495564 doi "https://doi.org/10.1016/j.medin.2013.08.006" @default.
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