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- W2005495653 abstract "5-Fluorouridine, in doses of 3.5 mmole/kg body wt, was injected 3 and 6 hr after d-galactosamine (1.85 mmole/kg) and the preventive effect on the liver injury was studied in comparison with equimolar doses of uridine in rats. The hepatic pools of UTP, UDP-glucose, and of other uracil nucleotides that were depleted by d-galactosamine were effectively replenished by formation of the respective 5-fluorouracil nucleotides. 5-Fluorouridine had a similar hepatoprotective effect as uridine when studied 12 or 24 hr after administration of d-galactosamine by measurement of four different enzyme activities in plasma as well as by light and electron microscopy of the liver tissue. 5-Fluorouridine was at least as effective as uridine in restoring the galactosamine-induced fragmentation of nucleoli indicating that transcription of preribosomal RNA, but not its complete maturation leading to new ribosomes, is a prerequisite for the intact nucleolar structure. In contrast to uridine, 5-fluorouridine was ineffective in supporting the replenishment of hepatic glycogen stores depleted by d-galactosamine. 5-Fluorouridine and d-galactosamine had an additive effect on the reduction of lipoproteins, phospholipids, and cholesterol in plasma and on the increase of hepatic fat, whereas uridine counteracted these changes. The replacement of uridine by 5-fluorouridine in the prevention of galactosamine-induced cell necrosis allows to discriminate between those metabolic lesions that are reversed by 5-fluorouridine as well as uridine, and may be involved in the sequence of events leading to hepatocellular necrosis, and those lesions that are reversed only by uridine but not by 5-fluorouridine and are therefore not critical for hepatocellular viability within at least 24 hr." @default.
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- W2005495653 date "1981-04-01" @default.
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- W2005495653 title "Preventive effects of 5-fluorouridine and uridine on d-galactosamine-induced liver injury" @default.
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- W2005495653 doi "https://doi.org/10.1016/0014-4800(81)90073-3" @default.
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