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- W2005497645 abstract "Heart failure is associated with reduction of exercise capacity that cannot be solely ascribed to reduced maximal oxygen uptake (VdotO2max). Therefore, research has focused on changes in skeletal muscle morphology, metabolism and function. Factors that can cause such changes in skeletal muscle comprise inactivity, malnutrition, constant or repeated episodes of inadequate oxygen delivery and prolonged exposure to altered neurohumoural stimuli. Most of these factors are not specific for the heart failure condition. On the other hand, heart failure is more than one clinical condition. Congestive heart failure (CHF) develops gradually as a result of deteriorating contractility of the viable myocardium, myocardial failure. Is it possible that development of this contractile deficit in the myocardium is paralleled by a corresponding contractile deficit of the skeletal muscles? This question cannot be answered today. Both patient studies and experimental studies support that there is a switch to a faster muscle phenotype and energy metabolism balance is more anaerobic. The muscle atrophy seen in many patients is not so evident in experimental studies. Few investigators have studied contractile function. Both fast twitch and slow twitch muscles seem to become slower, not faster as might be expected, and this is possibly linked to slower intracellular Ca2+ cycling. The neurohumoural stimuli that can cause this change are not known, but recently it has been reported that several cytokines are increased in CHF patients. Thus, the changes seen in skeletal muscles during CHF are partly secondary to inactivity, but the possibility remains that the contractility is altered because of intracellular changes of Ca2+ metabolism that are also seen in the myocardium." @default.
- W2005497645 created "2016-06-24" @default.
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- W2005497645 date "2001-03-01" @default.
- W2005497645 modified "2023-10-18" @default.
- W2005497645 title "Skeletal muscle disorders in heart failure" @default.
- W2005497645 cites W1848523579 @default.
- W2005497645 cites W1917158297 @default.
- W2005497645 cites W1964859779 @default.
- W2005497645 cites W1965801360 @default.
- W2005497645 cites W1966327507 @default.
- W2005497645 cites W1968301359 @default.
- W2005497645 cites W1969136722 @default.
- W2005497645 cites W1972370207 @default.
- W2005497645 cites W1972601624 @default.
- W2005497645 cites W1978495288 @default.
- W2005497645 cites W1981864649 @default.
- W2005497645 cites W1982851358 @default.
- W2005497645 cites W1983076149 @default.
- W2005497645 cites W1984121364 @default.
- W2005497645 cites W1985134920 @default.
- W2005497645 cites W1987388437 @default.
- W2005497645 cites W1989239545 @default.
- W2005497645 cites W1989889546 @default.
- W2005497645 cites W1990224341 @default.
- W2005497645 cites W1990961065 @default.
- W2005497645 cites W1994734582 @default.
- W2005497645 cites W1996495707 @default.
- W2005497645 cites W1997177813 @default.
- W2005497645 cites W2000636214 @default.
- W2005497645 cites W2003776648 @default.
- W2005497645 cites W2005835420 @default.
- W2005497645 cites W2009337098 @default.
- W2005497645 cites W2009728960 @default.
- W2005497645 cites W2012657513 @default.
- W2005497645 cites W2014211869 @default.
- W2005497645 cites W2015587956 @default.
- W2005497645 cites W2018766018 @default.
- W2005497645 cites W2020749347 @default.
- W2005497645 cites W2022579740 @default.
- W2005497645 cites W2033550072 @default.
- W2005497645 cites W2033652837 @default.
- W2005497645 cites W2035801904 @default.
- W2005497645 cites W2036424054 @default.
- W2005497645 cites W2036584028 @default.
- W2005497645 cites W2040479345 @default.
- W2005497645 cites W2048717364 @default.
- W2005497645 cites W2050466201 @default.
- W2005497645 cites W2050839858 @default.
- W2005497645 cites W2051129435 @default.
- W2005497645 cites W2061651179 @default.
- W2005497645 cites W2065445784 @default.
- W2005497645 cites W2065575480 @default.
- W2005497645 cites W2066050658 @default.
- W2005497645 cites W2068789420 @default.
- W2005497645 cites W2069212536 @default.
- W2005497645 cites W2069683756 @default.
- W2005497645 cites W2073994289 @default.
- W2005497645 cites W2085403456 @default.
- W2005497645 cites W2085640002 @default.
- W2005497645 cites W2086668012 @default.
- W2005497645 cites W2089194680 @default.
- W2005497645 cites W2090465644 @default.
- W2005497645 cites W2090525587 @default.
- W2005497645 cites W2090634060 @default.
- W2005497645 cites W2093779496 @default.
- W2005497645 cites W2093845352 @default.
- W2005497645 cites W2094221168 @default.
- W2005497645 cites W2094916097 @default.
- W2005497645 cites W2096696113 @default.
- W2005497645 cites W2101175755 @default.
- W2005497645 cites W2101990948 @default.
- W2005497645 cites W2114101618 @default.
- W2005497645 cites W2121664259 @default.
- W2005497645 cites W2124447358 @default.
- W2005497645 cites W2126012511 @default.
- W2005497645 cites W2130585822 @default.
- W2005497645 cites W2132571243 @default.
- W2005497645 cites W2133851654 @default.
- W2005497645 cites W2135400521 @default.
- W2005497645 cites W2142483199 @default.
- W2005497645 cites W2144598134 @default.
- W2005497645 cites W2146587637 @default.
- W2005497645 cites W2146644604 @default.
- W2005497645 cites W2148522618 @default.
- W2005497645 cites W2148959761 @default.
- W2005497645 cites W2149649063 @default.
- W2005497645 cites W2150560936 @default.
- W2005497645 cites W2156262323 @default.
- W2005497645 cites W2159120450 @default.
- W2005497645 cites W2160953740 @default.
- W2005497645 cites W2162786658 @default.
- W2005497645 cites W2167704737 @default.
- W2005497645 cites W2169169073 @default.
- W2005497645 cites W2178987521 @default.