Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005505655> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2005505655 endingPage "0" @default.
- W2005505655 startingPage "0" @default.
- W2005505655 abstract "Purpose A benzalkonium chloride (BAK)-free fixed-combination formulation of bimatoprost and timolol (Ganfort) has been developed for patients who are sensitive to preservatives. A randomized controlled study in 561 patients compared the IOP-lowering efficacy of the BAK-free formulation versus the preserved Ganfort. At all timepoints, IOP lowering, numerically, consistently favoured the BAK-free formulation. This finding contradicted expectations that the removal of BAK would result in lower ocular bioavailability of both bimatoprost and timolol, resulting in less efficacy. Research was conducted to explore possible explanation for the clinical observation. Methods Literature search on timolol dose response was performed, focusing on IOP lowering following topical dosing of 0.1%, 0.25%, and 0.5% timolol ophthalmic solutions. Results A U-shaped dose-response curve exists for timolol, and available data suggest that the dose that elicits maximal IOP lowering lies between 0.25% and 0.5%. Conclusion Removal of BAK from the fixed combination product Ganfort, which contains 0.5% timolol, may have resulted in a lower, but optimal, ocular concentration of timolol, leading to improved IOP-lowering efficacy with the preservative-free formulation. Commercial interest" @default.
- W2005505655 created "2016-06-24" @default.
- W2005505655 creator A5020564537 @default.
- W2005505655 creator A5035766382 @default.
- W2005505655 creator A5067000677 @default.
- W2005505655 date "2013-08-01" @default.
- W2005505655 modified "2023-09-26" @default.
- W2005505655 title "Removal of preservative from Ganfort improves intraocular pressure (IOP) lowering in patients - A timolol dose-response phenomenon" @default.
- W2005505655 doi "https://doi.org/10.1111/j.1755-3768.2013.4226.x" @default.
- W2005505655 hasPublicationYear "2013" @default.
- W2005505655 type Work @default.
- W2005505655 sameAs 2005505655 @default.
- W2005505655 citedByCount "0" @default.
- W2005505655 crossrefType "journal-article" @default.
- W2005505655 hasAuthorship W2005505655A5020564537 @default.
- W2005505655 hasAuthorship W2005505655A5035766382 @default.
- W2005505655 hasAuthorship W2005505655A5067000677 @default.
- W2005505655 hasBestOaLocation W20055056551 @default.
- W2005505655 hasConcept C118487528 @default.
- W2005505655 hasConcept C142724271 @default.
- W2005505655 hasConcept C2775919038 @default.
- W2005505655 hasConcept C2776521421 @default.
- W2005505655 hasConcept C2776740260 @default.
- W2005505655 hasConcept C2777336333 @default.
- W2005505655 hasConcept C2778073030 @default.
- W2005505655 hasConcept C2778527774 @default.
- W2005505655 hasConcept C2781092963 @default.
- W2005505655 hasConcept C42219234 @default.
- W2005505655 hasConcept C71924100 @default.
- W2005505655 hasConcept C98274493 @default.
- W2005505655 hasConceptScore W2005505655C118487528 @default.
- W2005505655 hasConceptScore W2005505655C142724271 @default.
- W2005505655 hasConceptScore W2005505655C2775919038 @default.
- W2005505655 hasConceptScore W2005505655C2776521421 @default.
- W2005505655 hasConceptScore W2005505655C2776740260 @default.
- W2005505655 hasConceptScore W2005505655C2777336333 @default.
- W2005505655 hasConceptScore W2005505655C2778073030 @default.
- W2005505655 hasConceptScore W2005505655C2778527774 @default.
- W2005505655 hasConceptScore W2005505655C2781092963 @default.
- W2005505655 hasConceptScore W2005505655C42219234 @default.
- W2005505655 hasConceptScore W2005505655C71924100 @default.
- W2005505655 hasConceptScore W2005505655C98274493 @default.
- W2005505655 hasLocation W20055056551 @default.
- W2005505655 hasOpenAccess W2005505655 @default.
- W2005505655 hasPrimaryLocation W20055056551 @default.
- W2005505655 hasRelatedWork W1557598834 @default.
- W2005505655 hasRelatedWork W164455875 @default.
- W2005505655 hasRelatedWork W1830729863 @default.
- W2005505655 hasRelatedWork W1966103856 @default.
- W2005505655 hasRelatedWork W2005505655 @default.
- W2005505655 hasRelatedWork W2006403852 @default.
- W2005505655 hasRelatedWork W2128476364 @default.
- W2005505655 hasRelatedWork W2169403898 @default.
- W2005505655 hasRelatedWork W2170698422 @default.
- W2005505655 hasRelatedWork W2291382200 @default.
- W2005505655 hasVolume "91" @default.
- W2005505655 isParatext "false" @default.
- W2005505655 isRetracted "false" @default.
- W2005505655 magId "2005505655" @default.
- W2005505655 workType "article" @default.