Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005507304> ?p ?o ?g. }
- W2005507304 endingPage "248" @default.
- W2005507304 startingPage "239" @default.
- W2005507304 abstract "Insulin receptor substrate (IRS) proteins have been shown to play an important role in breast cancer by differentially regulating cancer cell survival, proliferation, and motility. Furthermore, the IL-4-induced tyrosine phosphorylation of the transcription factor STAT6 was shown to protect breast cancer cells from apoptosis. Here, we analyzed human breast cancer tissues for the expression of IRS1, IRS2, STAT6, and tyrosine phosphorylated STAT6 (pSTAT6). We found that IRS1 and pSTAT6 were both highly expressed in ductal carcinoma in situ (DCIS). On the other hand, IRS2 expression was low in DCIS, but increased significantly in relation to tumor invasiveness. We utilized cell lines with disparate IRS1 expression, MDA-MB-231, MCF7, and MCF7 cells with depleted IRS1 due to shRNA lentiviral infection, to examine the role of IRS1 and IRS2 in the responsiveness of breast cancer cells to chemotherapy. We report that high IRS1 sensitized MCF7 cells to specific chemotherapeutic agents. These results suggest that high IRS1 with low IRS2 expression may predict the effectiveness of specific types of chemotherapy in breast cancer." @default.
- W2005507304 created "2016-06-24" @default.
- W2005507304 creator A5015540922 @default.
- W2005507304 creator A5016790638 @default.
- W2005507304 creator A5048079346 @default.
- W2005507304 creator A5069101329 @default.
- W2005507304 creator A5073715444 @default.
- W2005507304 date "2013-09-01" @default.
- W2005507304 modified "2023-09-30" @default.
- W2005507304 title "IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors" @default.
- W2005507304 cites W1511895445 @default.
- W2005507304 cites W1964811177 @default.
- W2005507304 cites W1966372986 @default.
- W2005507304 cites W1968975777 @default.
- W2005507304 cites W1983844193 @default.
- W2005507304 cites W1988428135 @default.
- W2005507304 cites W1991154919 @default.
- W2005507304 cites W2000111014 @default.
- W2005507304 cites W2001012596 @default.
- W2005507304 cites W2003670197 @default.
- W2005507304 cites W2007618944 @default.
- W2005507304 cites W2010223438 @default.
- W2005507304 cites W2013780430 @default.
- W2005507304 cites W2014887370 @default.
- W2005507304 cites W2015449775 @default.
- W2005507304 cites W2017828665 @default.
- W2005507304 cites W2021611918 @default.
- W2005507304 cites W2037866233 @default.
- W2005507304 cites W2038038133 @default.
- W2005507304 cites W2042878988 @default.
- W2005507304 cites W2043100327 @default.
- W2005507304 cites W2046161634 @default.
- W2005507304 cites W2047309202 @default.
- W2005507304 cites W2069834543 @default.
- W2005507304 cites W2071892147 @default.
- W2005507304 cites W2072603868 @default.
- W2005507304 cites W2082996869 @default.
- W2005507304 cites W2084252557 @default.
- W2005507304 cites W2084521532 @default.
- W2005507304 cites W2085921275 @default.
- W2005507304 cites W2096913544 @default.
- W2005507304 cites W2104466298 @default.
- W2005507304 cites W2108072032 @default.
- W2005507304 cites W2120863112 @default.
- W2005507304 cites W2123088183 @default.
- W2005507304 cites W2127612231 @default.
- W2005507304 cites W2135009937 @default.
- W2005507304 cites W2137395664 @default.
- W2005507304 cites W2139907742 @default.
- W2005507304 cites W2151055760 @default.
- W2005507304 cites W2157379134 @default.
- W2005507304 cites W2163825667 @default.
- W2005507304 cites W2166614155 @default.
- W2005507304 cites W2168243993 @default.
- W2005507304 cites W2172300820 @default.
- W2005507304 cites W2323269146 @default.
- W2005507304 cites W2328665307 @default.
- W2005507304 cites W2340925150 @default.
- W2005507304 cites W4253418569 @default.
- W2005507304 doi "https://doi.org/10.1016/j.canlet.2013.03.030" @default.
- W2005507304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3761875" @default.
- W2005507304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23562473" @default.
- W2005507304 hasPublicationYear "2013" @default.
- W2005507304 type Work @default.
- W2005507304 sameAs 2005507304 @default.
- W2005507304 citedByCount "59" @default.
- W2005507304 countsByYear W20055073042014 @default.
- W2005507304 countsByYear W20055073042015 @default.
- W2005507304 countsByYear W20055073042016 @default.
- W2005507304 countsByYear W20055073042017 @default.
- W2005507304 countsByYear W20055073042018 @default.
- W2005507304 countsByYear W20055073042019 @default.
- W2005507304 countsByYear W20055073042020 @default.
- W2005507304 countsByYear W20055073042021 @default.
- W2005507304 countsByYear W20055073042022 @default.
- W2005507304 countsByYear W20055073042023 @default.
- W2005507304 crossrefType "journal-article" @default.
- W2005507304 hasAuthorship W2005507304A5015540922 @default.
- W2005507304 hasAuthorship W2005507304A5016790638 @default.
- W2005507304 hasAuthorship W2005507304A5048079346 @default.
- W2005507304 hasAuthorship W2005507304A5069101329 @default.
- W2005507304 hasAuthorship W2005507304A5073715444 @default.
- W2005507304 hasBestOaLocation W20055073042 @default.
- W2005507304 hasConcept C112446052 @default.
- W2005507304 hasConcept C121608353 @default.
- W2005507304 hasConcept C126322002 @default.
- W2005507304 hasConcept C134018914 @default.
- W2005507304 hasConcept C143998085 @default.
- W2005507304 hasConcept C201624660 @default.
- W2005507304 hasConcept C2777391703 @default.
- W2005507304 hasConcept C2779306644 @default.
- W2005507304 hasConcept C2780862961 @default.
- W2005507304 hasConcept C502942594 @default.
- W2005507304 hasConcept C530470458 @default.
- W2005507304 hasConcept C71924100 @default.
- W2005507304 hasConcept C86803240 @default.
- W2005507304 hasConceptScore W2005507304C112446052 @default.
- W2005507304 hasConceptScore W2005507304C121608353 @default.