Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005507674> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2005507674 endingPage "447" @default.
- W2005507674 startingPage "437" @default.
- W2005507674 abstract "The effects of prostaglandin (PG) E1, E2, A1, F1α, F2α or D2 on the rat renal cortical, outer medullary and inner medullary adenylate cyclase-cyclic AM systems were examined. While high concentrations (8X10−4M) of each prostaglandin stimulated adenylate cyclase activity in each area of the kidney, PGE1 was the only prostaglandin to stimulate at 10−7M. PGA's were the only prostaglandins tested besides PGE's which stimulated adenylate cyclase at less than 10−4M. This effect of PGA's was limited to the outer medulla. PGD2 was the least stimulatory. Observations with renal slices yielded qualitatively results. The PGE's were the most potent in each area with PGA's only stimulatory in the outer medulla. O2 deprivation (5% O2) lowered the slice cyclic AMP content in each area of the kidney. In the cortex and outer medulla, prostaglandin mediated increases in cyclic AMP content were either lower or absent at 5% O2 compared to 95% O2. However, in the inner medulla PGE stimulation was observed only at 5% O2 and not 95% O2. No other prostaglandins were found to increase inner medullary cyclic AMP content at 95% or 5% O2. These results illustrate that the adenylate cyclase-cyclic AMP system responds uniquely to prostaglandins in each area of the kidney. Consideration of these results along with correlative observations suggests that inner medullary produced PGE's may act as local modulators of inner medullary adenylate cyclase." @default.
- W2005507674 created "2016-06-24" @default.
- W2005507674 creator A5031868103 @default.
- W2005507674 creator A5056721493 @default.
- W2005507674 date "1977-09-01" @default.
- W2005507674 modified "2023-10-16" @default.
- W2005507674 title "Effects of prostaglandins on rat renal adenylate cyclase-cyclic AMP systems" @default.
- W2005507674 cites W1601599671 @default.
- W2005507674 cites W1775749144 @default.
- W2005507674 cites W1938758335 @default.
- W2005507674 cites W1994114342 @default.
- W2005507674 cites W1997473454 @default.
- W2005507674 cites W2018373835 @default.
- W2005507674 cites W2022261416 @default.
- W2005507674 cites W2038811742 @default.
- W2005507674 cites W2045631314 @default.
- W2005507674 cites W2050771781 @default.
- W2005507674 cites W2074342717 @default.
- W2005507674 cites W2076610631 @default.
- W2005507674 cites W2091642142 @default.
- W2005507674 cites W2094648624 @default.
- W2005507674 cites W2149580519 @default.
- W2005507674 cites W2169503005 @default.
- W2005507674 cites W2424626638 @default.
- W2005507674 cites W2441742461 @default.
- W2005507674 doi "https://doi.org/10.1016/0090-6980(77)90259-3" @default.
- W2005507674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/198851" @default.
- W2005507674 hasPublicationYear "1977" @default.
- W2005507674 type Work @default.
- W2005507674 sameAs 2005507674 @default.
- W2005507674 citedByCount "21" @default.
- W2005507674 crossrefType "journal-article" @default.
- W2005507674 hasAuthorship W2005507674A5031868103 @default.
- W2005507674 hasAuthorship W2005507674A5056721493 @default.
- W2005507674 hasConcept C126322002 @default.
- W2005507674 hasConcept C134018914 @default.
- W2005507674 hasConcept C170493617 @default.
- W2005507674 hasConcept C17291353 @default.
- W2005507674 hasConcept C180526460 @default.
- W2005507674 hasConcept C185592680 @default.
- W2005507674 hasConcept C195121873 @default.
- W2005507674 hasConcept C24998067 @default.
- W2005507674 hasConcept C2777198256 @default.
- W2005507674 hasConcept C2777956040 @default.
- W2005507674 hasConcept C2779837120 @default.
- W2005507674 hasConcept C2780069284 @default.
- W2005507674 hasConcept C2780091579 @default.
- W2005507674 hasConcept C2780512574 @default.
- W2005507674 hasConcept C2780664492 @default.
- W2005507674 hasConcept C71924100 @default.
- W2005507674 hasConcept C86803240 @default.
- W2005507674 hasConceptScore W2005507674C126322002 @default.
- W2005507674 hasConceptScore W2005507674C134018914 @default.
- W2005507674 hasConceptScore W2005507674C170493617 @default.
- W2005507674 hasConceptScore W2005507674C17291353 @default.
- W2005507674 hasConceptScore W2005507674C180526460 @default.
- W2005507674 hasConceptScore W2005507674C185592680 @default.
- W2005507674 hasConceptScore W2005507674C195121873 @default.
- W2005507674 hasConceptScore W2005507674C24998067 @default.
- W2005507674 hasConceptScore W2005507674C2777198256 @default.
- W2005507674 hasConceptScore W2005507674C2777956040 @default.
- W2005507674 hasConceptScore W2005507674C2779837120 @default.
- W2005507674 hasConceptScore W2005507674C2780069284 @default.
- W2005507674 hasConceptScore W2005507674C2780091579 @default.
- W2005507674 hasConceptScore W2005507674C2780512574 @default.
- W2005507674 hasConceptScore W2005507674C2780664492 @default.
- W2005507674 hasConceptScore W2005507674C71924100 @default.
- W2005507674 hasConceptScore W2005507674C86803240 @default.
- W2005507674 hasIssue "3" @default.
- W2005507674 hasLocation W20055076741 @default.
- W2005507674 hasLocation W20055076742 @default.
- W2005507674 hasOpenAccess W2005507674 @default.
- W2005507674 hasPrimaryLocation W20055076741 @default.
- W2005507674 hasRelatedWork W1583211514 @default.
- W2005507674 hasRelatedWork W1968805583 @default.
- W2005507674 hasRelatedWork W1990936130 @default.
- W2005507674 hasRelatedWork W2002724911 @default.
- W2005507674 hasRelatedWork W2005507674 @default.
- W2005507674 hasRelatedWork W2031147569 @default.
- W2005507674 hasRelatedWork W2038811742 @default.
- W2005507674 hasRelatedWork W2048019637 @default.
- W2005507674 hasRelatedWork W2049338716 @default.
- W2005507674 hasRelatedWork W2410808285 @default.
- W2005507674 hasVolume "14" @default.
- W2005507674 isParatext "false" @default.
- W2005507674 isRetracted "false" @default.
- W2005507674 magId "2005507674" @default.
- W2005507674 workType "article" @default.