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- W2005514897 abstract "The role of the Angiotensin II type 2 receptor (AT2) in load-induced LV remodeling is highly controversial. To examine the function of the AT2 receptor in cardiac hypertrophy, ascending aortic stenosis (AS) was performed at 4 weeks of age in transgenic mice with ventricular myocyte-specific expression of AT2 (TG-AS, n = 42) and non-transgenic mice (NTG-AS, n = 45). Age-matched non-treated mice were used as controls. AT2 expression was driven by the MLC2v promoter. Survival of AS mice 70 days after operation was analyzed by the Kaplan-Meier approach. LV function 70 days or 10 days after AS was measured by LV catheterization. Myocyte diameter was assessed by confocal microscopy 70 days after AS. At day 70, survival rates of TG-AS and NTG-AS were similar (76.9% vs. 59.4%, p = NS by Log-rank). LV weight was increased in TG-AS compared to control (128±4 vs. 85±3 mg, p<0.001) and in NTG-AS (130±5 mg) vs. control (p<0.001), while the LV/BW ratio was also increased in TG-AS compared to control (4.39±0.12 vs. 2.85±0.04 mg/g, p<0.001) and NTG-AS (4.44±0.11 mg/g) vs. control (p<0.001). There were no differences in LV weight or LV/BW ratio between TG-AS and NTG-AS (p = NS). LV systolic pressure was increased in TG-AS (130±10 mmHg) and NTG-AS (191±12 mmHg) compared with control (86±6 mmHg; p<0.05 and p<0.001, respectively). However, LV systolic pressure was lower in TG-AS compared with NTG-AS (p<0.001). Cardiac myocyte diameter was increased in TG-AS compared with control (15.1±0.7 vs. 12.6±0.3 mm, p<0.01) and in NTG-AS (17.3±0.6 mm) vs. control (p<0.001); there was no difference between AS groups (p = NS). In animals 10 days after AS, there were significant increases in LV/BW ratio and LV systolic pressure in both TG-AS and NTG-AS compared with control, but no significant differences in either cardiac hypertrophy or elevation of LV systolic pressure between the TG-AS and NTG-AS groups were found, indicating consistent severity of aortic banding. Summary: Ventricular myocyte specific expression of AT2 does not inhibit or augment pathologic cardiac hypertrophy in response to chronic pressure overload." @default.
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- W2005514897 date "2004-08-01" @default.
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- W2005514897 title "Angiotensin II type 2 receptor expression in ventricular myocytes does not modify hypertrophic growth under chronic pressure overload" @default.
- W2005514897 doi "https://doi.org/10.1016/j.cardfail.2004.06.065" @default.
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