FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005526694> ?p ?o ?g. }

• W2005526694 endingPage "481" @default.
• W2005526694 startingPage "464" @default.
• W2005526694 abstract "The neurotensin receptor (NTS1) has emerged as an interesting target for molecular imaging and radiotherapy of NTS-positive tumors due to the overexpression in a range of tumors. The aim of this study was to develop a 177Lu-labeled NTS1 radioligand, its application for radiotherapy in a preclinical model and the imaging of therapy success by small-animal positron emission tomography (µPET) using [68Ga]DOTA-RGD as a specific tracer for imaging angiogenesis. The 177Lu-labeled peptide was subjected to studies on HT29-tumor-bearing nude mice in vivo, defining four groups of animals (single dose, two fractionated doses, four fractionated doses and sham-treated animals). Body weight and tumor diameters were determined three times per week. Up to day 28 after treatment, µPET studies were performed with [68Ga]DOTA-RGD. At days 7-10 after treatment with four fractionated doses of 11-14 MBq (each at days 0, 3, 6 and 10), the tumor growth was slightly decreased in comparison with untreated animals. Using a single high dose of 51 MBq, a significantly decreased tumor diameter of about 50% was observed with the beginning of treatment. Our preliminary PET imaging data suggested decreased tumor uptake values of [68Ga]DOTA-RGD in treated animals compared to controls at day 7 after treatment. This pilot study suggests that early PET imaging with [68Ga]DOTA-RGD in radiotherapy studies to monitor integrin expression could be a promising tool to predict therapy success in vivo. Further successive PET experiments are needed to confirm the significance and predictive value of RGD-PET for NTS-mediated radiotherapy." @default.
• W2005526694 created "2016-06-24" @default.
• W2005526694 creator A5033659234 @default.
• W2005526694 creator A5043047263 @default.
• W2005526694 creator A5056056907 @default.
• W2005526694 creator A5058272199 @default.
• W2005526694 creator A5073657268 @default.
• W2005526694 creator A5077009005 @default.
• W2005526694 creator A5078759393 @default.
• W2005526694 creator A5081248127 @default.
• W2005526694 creator A5084855474 @default.
• W2005526694 date "2014-04-16" @default.
• W2005526694 modified "2023-09-23" @default.
• W2005526694 title "In Vivo Monitoring of the Antiangiogenic Effect of Neurotensin Receptor-Mediated Radiotherapy by Small-Animal Positron Emission Tomography: A Pilot Study" @default.
• W2005526694 cites W1542870268 @default.
• W2005526694 cites W1607957872 @default.
• W2005526694 cites W1775749144 @default.
• W2005526694 cites W1966286364 @default.
• W2005526694 cites W1970874936 @default.
• W2005526694 cites W1976315283 @default.
• W2005526694 cites W1980117828 @default.
• W2005526694 cites W1980437042 @default.
• W2005526694 cites W1989264888 @default.
• W2005526694 cites W1991849045 @default.
• W2005526694 cites W1993961771 @default.
• W2005526694 cites W1994452545 @default.
• W2005526694 cites W1995823770 @default.
• W2005526694 cites W1998366881 @default.
• W2005526694 cites W2016811630 @default.
• W2005526694 cites W2021307862 @default.
• W2005526694 cites W2023822951 @default.
• W2005526694 cites W2035419452 @default.
• W2005526694 cites W2036948551 @default.
• W2005526694 cites W2038039985 @default.
• W2005526694 cites W2043635035 @default.
• W2005526694 cites W2047587322 @default.
• W2005526694 cites W2050488663 @default.
• W2005526694 cites W2053074318 @default.
• W2005526694 cites W2058130105 @default.
• W2005526694 cites W2058921839 @default.
• W2005526694 cites W2061033181 @default.
• W2005526694 cites W2074012988 @default.
• W2005526694 cites W2074631079 @default.
• W2005526694 cites W2087141215 @default.
• W2005526694 cites W2115989405 @default.
• W2005526694 cites W2124078130 @default.
• W2005526694 cites W2124948344 @default.
• W2005526694 cites W2152450078 @default.
• W2005526694 cites W2158726390 @default.
• W2005526694 cites W2159606669 @default.
• W2005526694 cites W2162455656 @default.
• W2005526694 cites W2166132430 @default.
• W2005526694 cites W2316405247 @default.
• W2005526694 cites W2332827624 @default.
• W2005526694 cites W2949544505 @default.
• W2005526694 doi "https://doi.org/10.3390/ph7040464" @default.
• W2005526694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4014703" @default.
• W2005526694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24743103" @default.
• W2005526694 hasPublicationYear "2014" @default.
• W2005526694 type Work @default.
• W2005526694 sameAs 2005526694 @default.
• W2005526694 citedByCount "18" @default.
• W2005526694 countsByYear W20055266942014 @default.
• W2005526694 countsByYear W20055266942016 @default.
• W2005526694 countsByYear W20055266942017 @default.
• W2005526694 countsByYear W20055266942018 @default.
• W2005526694 countsByYear W20055266942019 @default.
• W2005526694 countsByYear W20055266942020 @default.
• W2005526694 countsByYear W20055266942021 @default.
• W2005526694 countsByYear W20055266942022 @default.
• W2005526694 countsByYear W20055266942023 @default.
• W2005526694 crossrefType "journal-article" @default.
• W2005526694 hasAuthorship W2005526694A5033659234 @default.
• W2005526694 hasAuthorship W2005526694A5043047263 @default.
• W2005526694 hasAuthorship W2005526694A5056056907 @default.
• W2005526694 hasAuthorship W2005526694A5058272199 @default.
• W2005526694 hasAuthorship W2005526694A5073657268 @default.
• W2005526694 hasAuthorship W2005526694A5077009005 @default.
• W2005526694 hasAuthorship W2005526694A5078759393 @default.
• W2005526694 hasAuthorship W2005526694A5081248127 @default.
• W2005526694 hasAuthorship W2005526694A5084855474 @default.
• W2005526694 hasBestOaLocation W20055266941 @default.
• W2005526694 hasConcept C118303440 @default.
• W2005526694 hasConcept C126322002 @default.
• W2005526694 hasConcept C142724271 @default.
• W2005526694 hasConcept C150903083 @default.
• W2005526694 hasConcept C170493617 @default.
• W2005526694 hasConcept C199374082 @default.
• W2005526694 hasConcept C207001950 @default.
• W2005526694 hasConcept C2775842073 @default.
• W2005526694 hasConcept C2778976297 @default.
• W2005526694 hasConcept C2779931791 @default.
• W2005526694 hasConcept C2780394083 @default.
• W2005526694 hasConcept C29331040 @default.
• W2005526694 hasConcept C2989005 @default.
• W2005526694 hasConcept C2993559085 @default.
• W2005526694 hasConcept C3017724952 @default.
• W2005526694 hasConcept C502942594 @default.

• next