FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005540893> ?p ?o ?g. }

• W2005540893 endingPage "2504" @default.
• W2005540893 startingPage "2499" @default.
• W2005540893 abstract "We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological disease. CD40L-positive cells were co-localized with CD40-bearing cells in active lesions (perivascular infiltrates). Most of these CD40-bearing cells proved to be of the monocytic lineage (macrophages or microglial cells), and relatively few were B cells. To functionally evaluate CD40-CD40L interactions, EAE was elicited in mice by means of proteolipid-peptide immunization. Treatment with anti-CD40L monoclonal antibody completely prevented the development of disease. Furthermore, administration of anti-CD40L monoclonal antibody, even after disease onset, shortly before maximum disability score was reached led to dramatic disease reduction. The presence of helper T cells expressing CD40L in brain tissue of MS patients and EAE animals, together with the functional evidence provided by successful experimental prevention and therapy in an animal model, indicates that blockade of CD40-CD40L-mediated cellular interactions may be a method for interference in active MS." @default.
• W2005540893 created "2016-06-24" @default.
• W2005540893 creator A5012392552 @default.
• W2005540893 creator A5024548289 @default.
• W2005540893 creator A5049353510 @default.
• W2005540893 creator A5050616725 @default.
• W2005540893 creator A5052281886 @default.
• W2005540893 creator A5081441218 @default.
• W2005540893 creator A5090327278 @default.
• W2005540893 date "1996-03-19" @default.
• W2005540893 modified "2023-09-26" @default.
• W2005540893 title "CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis." @default.
• W2005540893 cites W1544641340 @default.
• W2005540893 cites W1978689177 @default.
• W2005540893 cites W1987968095 @default.
• W2005540893 cites W1996315014 @default.
• W2005540893 cites W2008236686 @default.
• W2005540893 cites W2017142317 @default.
• W2005540893 cites W2020148917 @default.
• W2005540893 cites W2033202090 @default.
• W2005540893 cites W2042202031 @default.
• W2005540893 cites W2044973011 @default.
• W2005540893 cites W2054248637 @default.
• W2005540893 cites W2057997204 @default.
• W2005540893 cites W2063820008 @default.
• W2005540893 cites W2067014075 @default.
• W2005540893 cites W2068488477 @default.
• W2005540893 cites W2069784383 @default.
• W2005540893 cites W2069907490 @default.
• W2005540893 cites W2075942913 @default.
• W2005540893 cites W2097852478 @default.
• W2005540893 cites W2109863933 @default.
• W2005540893 cites W2111837231 @default.
• W2005540893 cites W2133128339 @default.
• W2005540893 cites W2134453100 @default.
• W2005540893 cites W2147715156 @default.
• W2005540893 cites W2168931543 @default.
• W2005540893 cites W2188851680 @default.
• W2005540893 cites W2201437726 @default.
• W2005540893 doi "https://doi.org/10.1073/pnas.93.6.2499" @default.
• W2005540893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39826" @default.
• W2005540893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8637903" @default.
• W2005540893 hasPublicationYear "1996" @default.
• W2005540893 type Work @default.
• W2005540893 sameAs 2005540893 @default.
• W2005540893 citedByCount "463" @default.
• W2005540893 countsByYear W20055408932012 @default.
• W2005540893 countsByYear W20055408932013 @default.
• W2005540893 countsByYear W20055408932014 @default.
• W2005540893 countsByYear W20055408932015 @default.
• W2005540893 countsByYear W20055408932016 @default.
• W2005540893 countsByYear W20055408932017 @default.
• W2005540893 countsByYear W20055408932018 @default.
• W2005540893 countsByYear W20055408932019 @default.
• W2005540893 countsByYear W20055408932020 @default.
• W2005540893 countsByYear W20055408932021 @default.
• W2005540893 countsByYear W20055408932022 @default.
• W2005540893 countsByYear W20055408932023 @default.
• W2005540893 crossrefType "journal-article" @default.
• W2005540893 hasAuthorship W2005540893A5012392552 @default.
• W2005540893 hasAuthorship W2005540893A5024548289 @default.
• W2005540893 hasAuthorship W2005540893A5049353510 @default.
• W2005540893 hasAuthorship W2005540893A5050616725 @default.
• W2005540893 hasAuthorship W2005540893A5052281886 @default.
• W2005540893 hasAuthorship W2005540893A5081441218 @default.
• W2005540893 hasAuthorship W2005540893A5090327278 @default.
• W2005540893 hasBestOaLocation W20055408932 @default.
• W2005540893 hasConcept C154317977 @default.
• W2005540893 hasConcept C159654299 @default.
• W2005540893 hasConcept C202751555 @default.
• W2005540893 hasConcept C203014093 @default.
• W2005540893 hasConcept C2777899865 @default.
• W2005540893 hasConcept C2778486448 @default.
• W2005540893 hasConcept C2780640218 @default.
• W2005540893 hasConcept C39347974 @default.
• W2005540893 hasConcept C542903549 @default.
• W2005540893 hasConcept C55493867 @default.
• W2005540893 hasConcept C71924100 @default.
• W2005540893 hasConcept C86803240 @default.
• W2005540893 hasConceptScore W2005540893C154317977 @default.
• W2005540893 hasConceptScore W2005540893C159654299 @default.
• W2005540893 hasConceptScore W2005540893C202751555 @default.
• W2005540893 hasConceptScore W2005540893C203014093 @default.
• W2005540893 hasConceptScore W2005540893C2777899865 @default.
• W2005540893 hasConceptScore W2005540893C2778486448 @default.
• W2005540893 hasConceptScore W2005540893C2780640218 @default.
• W2005540893 hasConceptScore W2005540893C39347974 @default.
• W2005540893 hasConceptScore W2005540893C542903549 @default.
• W2005540893 hasConceptScore W2005540893C55493867 @default.
• W2005540893 hasConceptScore W2005540893C71924100 @default.
• W2005540893 hasConceptScore W2005540893C86803240 @default.
• W2005540893 hasIssue "6" @default.
• W2005540893 hasLocation W20055408931 @default.
• W2005540893 hasLocation W20055408932 @default.
• W2005540893 hasLocation W20055408933 @default.
• W2005540893 hasLocation W20055408934 @default.
• W2005540893 hasLocation W20055408935 @default.
• W2005540893 hasLocation W20055408936 @default.

• next