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• W2005559056 abstract "Despite their similar spindle-shaped appearance, periodontal ligament fibroblasts (PDLF) and gingival fibroblasts (GF) appear to display distinct functional activities in the maintenance of tissue integrity and during inflammatory/immune responses. We postulated that different characteristics of PDLF and GF are defined by the differential expression of specific genes. To test this, we investigated the possible variance of gene expression profile between cultured PDLF and GF, using DNA microarray technology. One hundred sixty-three genes were found differentially expressed by at least three-fold between PDLF and GF. Genes encoding transmembrane proteins and cytoskeleton-related proteins tended to be up-regulated in PDLF, whereas genes encoding cell-cycle regulation proteins and metabolism-related proteins tended to be up-regulated in GF. We concluded that PDLF and GF appear to display different gene expression patterns that may reflect intrinsic functional differences of the two cell populations and may well coordinate with their tissue-specific activities." @default.
• W2005559056 created "2016-06-24" @default.
• W2005559056 creator A5007239313 @default.
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• W2005559056 date "2002-06-01" @default.
• W2005559056 modified "2023-10-18" @default.
• W2005559056 title "Identification of Genes Differentially Expressed in Cultured Human Periodontal Ligament Fibroblasts <i>vs.</i> Human Gingival Fibroblasts by DNA Microarray Analysis" @default.
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• W2005559056 doi "https://doi.org/10.1177/154405910208100609" @default.
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