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• W2005566904 abstract "We report a case of a 27-year-old woman with a nonpigmented lesion on the right scalp. Histological examination showed a malignant nodular neoplasm with 2 distinct but intimately admixed components: a malignant melanoma with a spindle component and an unusual glandular component. Immunohistochemical studies demonstrated epithelial differentiation on the basis of cytokeratin (CAM5.2 and AE1/AE3) expression in the glandular component and melanocytic differentiation (HMB-45, PNL2, MITF, and S-100) of the spindle cell component. A single melanocytic marker (MITF) was expressed in both components, raising the possibility of dual differentiation in a single tumor, rather than the alternative considerations of a collision tumor or a reactive pseudoepitheliomatous hyperplasia with eccrine duct lumen formation within a melanoma. This unusual tumor with both melanocytic and epithelial components may represent a true melanocarcinoma, which becomes a plausible consideration, in view of melanoma plasticity and recent experimental evidence and speculation about the role of stem cells in melanoma." @default.
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• W2005566904 date "2007-08-01" @default.
• W2005566904 modified "2023-09-26" @default.
• W2005566904 title "Unusual Occurrence of a Melanoma with Intermixed Epithelial Component: A True Melanocarcinoma?: Case Report and Review of Epithelial Differentiation in Melanoma by Light Microscopy and Immunohistochemistry" @default.
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• W2005566904 doi "https://doi.org/10.1097/dad.0b013e31812f5235" @default.
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