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• W2005581220 startingPage "2215" @default.
• W2005581220 abstract "Two variants in immunoglobulin heavy chain production, derived from the MPC 11 mouse myeloma cell line, make short heavy (H) chains with identical precise deletions of the CH3 domain. The CH3 domain is expressed in the H chain mRNA from both variants. Although in vitro translation of this mRNA produces one H chain species, deleted heavy chains are secreted as heavy-light (HL) and H2L2 moieties in contrast to MPC 11, which secretes only H2L2 . The heavy chains of HL apparently contain more carbohydrate (CHO+) than do the H chains of H2L2 , and inhibition of N-linked glycosylation results in the secretion of relatively more H2L2 . Here we present evidence suggesting that (a) the absence of the CH3 domain has led to conformational changes in these molecules, (b) these changes permit posttranslational glycosylation, and (c) unrestrained glycosylation can frequently yield unusual CHO+ structures that make complete assembly unlikely." @default.
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• W2005581220 date "1984-06-01" @default.
• W2005581220 modified "2023-09-23" @default.
• W2005581220 title "Mouse myeloma cells that make short immunoglobulin heavy chains: pleiotropic effects on glycosylation and chain assembly." @default.
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• W2005581220 doi "https://doi.org/10.1083/jcb.98.6.2215" @default.
• W2005581220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2113058" @default.
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