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• W2005581710 abstract "Multidrug-resistance (MDR) genes are induced in the liver of rodents treated with a variety of foreign chemicals and hepatocarcinogens. It has been reported that 2,3,6,7-tetrachlorodibenzo-p-dioxin (TCDD) might increase hepatic MDR transcripts in the Fischer rat and the C57BL/6 (B6) inbred mouse strain having the high-affinity aromatic hydrocarbon (Ah) receptor, but not in the DBA/2 (D2) strain having the low-affinity Ah receptor. These intriguing results suggest that TCDD might activate MDR gene expression by way of an Ah receptor-mediated signal transduction pathway. We have attempted to confirm these data in four inbred mouse strains: two (B6 and BALB/c) having the high-affinity Ah receptor, and two (D2 and AKR) having the low-affinity Ah receptor. The RNase protection assay was used to distinguish between the MDR1, MDR2, and MDR3 mRNAs. TCDD treatment at high (100 μg/kg) and low (1 μ/kg) doses, a time course from 6 to 96 hr of TCDD treatment, progeny from the B6D2F1 Χ D2 backcross, and transcriptional run-on experiments were performed. The Cypla-1 (cytochrome P1450) and Nmo-1 [NAD(P)H:menadione oxidoreductase] genes, two members of the TCDD-inducible [Ah] battery, were used as positive controls. We were unable to detect significant coinduction of MDR1, MDR2, or MDR3 mRNA with CYP1A1 mRNA or with Cypla-1 or Nmo-1 transcription under any conditions. Therefore, we conclude that any effects that TCDD might have on MDR expression must be substantially different from TCDD effects on genes known to be induced via the Ah receptor." @default.
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• W2005581710 date "1991-07-01" @default.
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• W2005581710 title "Murine<i>mdr-1, mdr-2,</i>and<i>mdr-3</i>Gene Expression: No Coinduction with the<i>Cypla-1</i>and<i>Nmo-1</i>Genes in Liver by 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin" @default.
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• W2005581710 doi "https://doi.org/10.1089/dna.1991.10.433" @default.
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