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- W2005582458 abstract "Abstract The aim of this study was to test the effect of antioxidants on enzymatic abnormalities and free radicals-modified DNA adducts associated with pre-malignant changes in HP-negative chronic atrophic gastritis (CAG) patients. 60 patients with CAG and intestinal metaplasia underwent a GI endoscopy with biopsy samples for histology and for: alpha-tocopherol, malonyldialdehyde, xanthine oxidase (XO), ornithine decarboxylase (ODC) and 8-hydroxydeoxyguanosine (8-OhdG). Patients were randomly allocated into three groups supplemented for 6 months with: (A) vitamin E, 300 mg/day; (B) Multivitamin, 2 tablets/day and (C) a certified fermented papaya preparation 6 g/nocte (Immune-Age FPP, Osato Research Institute, Gifu, Japan). Ten dyspeptic patients without histological abnormalities served as control. Histological and biochemical parameters were blindly repeated at 3 and 6 months. Plasma oxidant/antioxidant status was normal in all groups. CAG patients had a significantly (p" @default.
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- W2005582458 date "2003-08-01" @default.
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- W2005582458 title "Atrophic/metaplastic changes of gastric mucosa: a preliminary interventional trial comparing different antioxidant supplements" @default.
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- W2005582458 doi "https://doi.org/10.1016/s0531-5131(03)00241-3" @default.
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