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- W2005585890 abstract "We have analyzed amino acid, nucleotide sequence, and RNA secondary structure variability in the env gene of human immunodeficiency virus type (HIV-1). In applying algorithms for computing optimal RNA-folding patterns to a nonredundant data set of 178 env nucleotide sequences, we found a conserved RNA stem-loop structure in the first conserved (C1) region of the env gene. This detailed examination also revealed the known secondary structure conservation of the Rev-responsive element (RRE). This finding is also supported by a higher third position conservation of the translatable reading frame along these subregions. The typical folding of the C1 region consists of two isolated stem-loop structures. These highly conserved structures are likely to have a biological function. This assumption is supported by the conservation of the third position along the coding region of these structures. The third position retains a conservation level above what would be statistically expected." @default.
- W2005585890 created "2016-06-24" @default.
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- W2005585890 date "2002-08-20" @default.
- W2005585890 modified "2023-09-23" @default.
- W2005585890 title "RNA Secondary Structure and Sequence Conservation in C1 Region of Human Immunodeficiency Virus Type 1envGene" @default.
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- W2005585890 doi "https://doi.org/10.1089/08892220260190353" @default.
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