FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005592012> ?p ?o ?g. }

• W2005592012 endingPage "737" @default.
• W2005592012 startingPage "731" @default.
• W2005592012 abstract "Abstract Genotoxicity assays were conducted on rats treated with benzo[ a ]pyrene (BaP) as part of Stage III of a validation study on the Pig‐a gene mutation assay. Assays were performed at the U.S. FDA‐NCTR and Bayer‐Germany. Starting on Day 1, groups of five 6‐ to 7‐week‐old male Fischer 344 (F344, used at FDA‐NCTR) and Han Wistar rats (Bayer) were given 28 daily doses of 0, 37.5, 75, or 150 mg/kg BaP; blood was sampled on Days −1, 4, 15, 29, and 56. Pig‐a mutant frequencies were determined on Days −1, 15, 29, and 56 in total red blood cells (RBCs) and reticulocytes (RETs) as RBC CD59− and RET CD59− frequencies; percent micronucleated‐RETs (%MN‐RET) were measured on Days 4 and 29. RBC CD59− and RET CD59− frequencies increased in a dose‐ and time‐dependent manner, producing significant increases by Day 29 in both rat models. The responses for RETs were stronger than those for RBCs, and the responses in F344 rats were stronger than in Han Wistar rats. BaP also produced significant increases in %MN‐RET frequency at Days 4 and 29, with the responses being greater in F344 than Han Wistar rats. The overall findings were consistent with those of the reference laboratory using Han Wistar rats. Finally, mutation assays performed on splenocytes from Day 56 F344 rats indicated that BaP mutant frequencies were three to fivefold higher for the Hprt gene than the Pig‐a gene. The results indicate that the Pig‐a RET and RBC assays are reproducible, transferable, and show promise for integrating gene mutation into 28‐day repeat‐dose studies. Environ. Mol. Mutagen. 2011. © 2011 Wiley‐Liss, Inc." @default.
• W2005592012 created "2016-06-24" @default.
• W2005592012 creator A5029552903 @default.
• W2005592012 creator A5035119519 @default.
• W2005592012 creator A5079208384 @default.
• W2005592012 creator A5080622100 @default.
• W2005592012 creator A5080974424 @default.
• W2005592012 creator A5086028954 @default.
• W2005592012 creator A5091403004 @default.
• W2005592012 date "2011-08-29" @default.
• W2005592012 modified "2023-10-17" @default.
• W2005592012 title "Report on stage III Pig-a mutation assays using benzo[a]pyrene" @default.
• W2005592012 cites W1970948623 @default.
• W2005592012 cites W1971848209 @default.
• W2005592012 cites W1972210058 @default.
• W2005592012 cites W1988684445 @default.
• W2005592012 cites W2006060399 @default.
• W2005592012 cites W2022070266 @default.
• W2005592012 cites W2038251476 @default.
• W2005592012 cites W2040926324 @default.
• W2005592012 cites W2042005810 @default.
• W2005592012 cites W2043686217 @default.
• W2005592012 cites W2045381833 @default.
• W2005592012 cites W2051467001 @default.
• W2005592012 cites W2056370789 @default.
• W2005592012 cites W2057808953 @default.
• W2005592012 cites W2058377679 @default.
• W2005592012 cites W2062013900 @default.
• W2005592012 cites W2066203014 @default.
• W2005592012 cites W2077791352 @default.
• W2005592012 cites W2078766596 @default.
• W2005592012 cites W2082791745 @default.
• W2005592012 cites W2110097285 @default.
• W2005592012 cites W2138985153 @default.
• W2005592012 cites W2146021438 @default.
• W2005592012 cites W2166047607 @default.
• W2005592012 cites W2168131458 @default.
• W2005592012 cites W2169679511 @default.
• W2005592012 cites W2170317227 @default.
• W2005592012 doi "https://doi.org/10.1002/em.20675" @default.
• W2005592012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22052432" @default.
• W2005592012 hasPublicationYear "2011" @default.
• W2005592012 type Work @default.
• W2005592012 sameAs 2005592012 @default.
• W2005592012 citedByCount "37" @default.
• W2005592012 countsByYear W20055920122012 @default.
• W2005592012 countsByYear W20055920122013 @default.
• W2005592012 countsByYear W20055920122014 @default.
• W2005592012 countsByYear W20055920122015 @default.
• W2005592012 countsByYear W20055920122016 @default.
• W2005592012 countsByYear W20055920122017 @default.
• W2005592012 countsByYear W20055920122018 @default.
• W2005592012 countsByYear W20055920122019 @default.
• W2005592012 countsByYear W20055920122020 @default.
• W2005592012 countsByYear W20055920122022 @default.
• W2005592012 crossrefType "journal-article" @default.
• W2005592012 hasAuthorship W2005592012A5029552903 @default.
• W2005592012 hasAuthorship W2005592012A5035119519 @default.
• W2005592012 hasAuthorship W2005592012A5079208384 @default.
• W2005592012 hasAuthorship W2005592012A5080622100 @default.
• W2005592012 hasAuthorship W2005592012A5080974424 @default.
• W2005592012 hasAuthorship W2005592012A5086028954 @default.
• W2005592012 hasAuthorship W2005592012A5091403004 @default.
• W2005592012 hasConcept C104317684 @default.
• W2005592012 hasConcept C114246631 @default.
• W2005592012 hasConcept C126322002 @default.
• W2005592012 hasConcept C143065580 @default.
• W2005592012 hasConcept C153911025 @default.
• W2005592012 hasConcept C16685009 @default.
• W2005592012 hasConcept C185592680 @default.
• W2005592012 hasConcept C2776639595 @default.
• W2005592012 hasConcept C2777538855 @default.
• W2005592012 hasConcept C2778959862 @default.
• W2005592012 hasConcept C29730261 @default.
• W2005592012 hasConcept C2994225774 @default.
• W2005592012 hasConcept C501734568 @default.
• W2005592012 hasConcept C55493867 @default.
• W2005592012 hasConcept C71924100 @default.
• W2005592012 hasConcept C86803240 @default.
• W2005592012 hasConceptScore W2005592012C104317684 @default.
• W2005592012 hasConceptScore W2005592012C114246631 @default.
• W2005592012 hasConceptScore W2005592012C126322002 @default.
• W2005592012 hasConceptScore W2005592012C143065580 @default.
• W2005592012 hasConceptScore W2005592012C153911025 @default.
• W2005592012 hasConceptScore W2005592012C16685009 @default.
• W2005592012 hasConceptScore W2005592012C185592680 @default.
• W2005592012 hasConceptScore W2005592012C2776639595 @default.
• W2005592012 hasConceptScore W2005592012C2777538855 @default.
• W2005592012 hasConceptScore W2005592012C2778959862 @default.
• W2005592012 hasConceptScore W2005592012C29730261 @default.
• W2005592012 hasConceptScore W2005592012C2994225774 @default.
• W2005592012 hasConceptScore W2005592012C501734568 @default.
• W2005592012 hasConceptScore W2005592012C55493867 @default.
• W2005592012 hasConceptScore W2005592012C71924100 @default.
• W2005592012 hasConceptScore W2005592012C86803240 @default.
• W2005592012 hasIssue "9" @default.
• W2005592012 hasLocation W20055920121 @default.
• W2005592012 hasLocation W20055920122 @default.

• next