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• W2005603603 abstract "The best established proteolytic event of osteoclasts is bone matrix solubilization by the cysteine proteinase cathepsin K. Here, however, we draw the attention on osteoclastic activities depending on matrix metalloproteinases (MMPs). We discuss the observations supporting that MMPs contribute significantly to bone matrix solubilization in specific areas of the skeleton and in some developmental and pathological situations. Our discussion takes into account (1) the characteristics of the bone remodeling persisting in the absence of cathepsin K, (2) the ultrastructure of the resorption zone in response to inactivation of MMPs and of cathepsin K in different bone types, (3) bone resorption levels in MMP knockout mice compared to wild-type mice, (4) the identification of MMPs in osteoclasts and surrounding cells, and (5) the effect of different bone pathologies on the serum concentrations of specific collagen fragments believed to discriminate between cathepsin K and MMP cleavage. Next, we provide evidence that MMPs are very critical for osteoclast migration, thereby controlling also the cell-matrix interactions required for cell attachment/detachment. The evidence supporting this role is based on a model of osteoclast recruitment in primitive long bones, an assay of osteoclast invasion through collagen gel, and the effect of proteinase inhibitors/knockouts in these models. Furthermore, we mention observations indicating a role of MMPs in initiation of bone resorption. Finally, we emphasize the many distinct ways MMPs may alter focally the extracellular environment thereby regulating the osteoclast behavior. Although the understanding of MMPs in osteoclast biology is rapidly expanding, it is suspected that important roles remain to be discovered." @default.
• W2005603603 created "2016-06-24" @default.
• W2005603603 creator A5001350750 @default.
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• W2005603603 creator A5059821476 @default.
• W2005603603 creator A5071476269 @default.
• W2005603603 creator A5082542112 @default.
• W2005603603 date "2003-07-18" @default.
• W2005603603 modified "2023-09-29" @default.
• W2005603603 title "Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities" @default.
• W2005603603 cites W1511482991 @default.
• W2005603603 cites W1574172480 @default.
• W2005603603 cites W1583830460 @default.
• W2005603603 cites W168147309 @default.
• W2005603603 cites W1895902281 @default.
• W2005603603 cites W1903249652 @default.
• W2005603603 cites W1924436749 @default.
• W2005603603 cites W1952946804 @default.
• W2005603603 cites W1953148896 @default.
• W2005603603 cites W1963796764 @default.
• W2005603603 cites W1967676673 @default.
• W2005603603 cites W1968024679 @default.
• W2005603603 cites W1968084778 @default.
• W2005603603 cites W1968298061 @default.
• W2005603603 cites W1971000202 @default.
• W2005603603 cites W1971244052 @default.
• W2005603603 cites W1974784538 @default.
• W2005603603 cites W1984965767 @default.
• W2005603603 cites W1985744266 @default.
• W2005603603 cites W1989318637 @default.
• W2005603603 cites W1991227464 @default.
• W2005603603 cites W1991347326 @default.
• W2005603603 cites W1991674531 @default.
• W2005603603 cites W1995648313 @default.
• W2005603603 cites W1996682859 @default.
• W2005603603 cites W1996874799 @default.
• W2005603603 cites W1997892080 @default.
• W2005603603 cites W2000983409 @default.
• W2005603603 cites W2001821836 @default.
• W2005603603 cites W2006245117 @default.
• W2005603603 cites W2016411107 @default.
• W2005603603 cites W2016484384 @default.
• W2005603603 cites W2017945794 @default.
• W2005603603 cites W2019522034 @default.
• W2005603603 cites W2020544906 @default.
• W2005603603 cites W2020891044 @default.
• W2005603603 cites W2022281511 @default.
• W2005603603 cites W2025062557 @default.
• W2005603603 cites W2025097349 @default.
• W2005603603 cites W2027069366 @default.
• W2005603603 cites W2027852937 @default.
• W2005603603 cites W2029347297 @default.
• W2005603603 cites W2030164378 @default.
• W2005603603 cites W2030240788 @default.
• W2005603603 cites W2035458683 @default.
• W2005603603 cites W2036300408 @default.
• W2005603603 cites W2039002419 @default.
• W2005603603 cites W2042303782 @default.
• W2005603603 cites W2043068076 @default.
• W2005603603 cites W2043498363 @default.
• W2005603603 cites W2044981350 @default.
• W2005603603 cites W2048299560 @default.
• W2005603603 cites W2054358569 @default.
• W2005603603 cites W2055102124 @default.
• W2005603603 cites W2058616210 @default.
• W2005603603 cites W2058873146 @default.
• W2005603603 cites W2059018472 @default.
• W2005603603 cites W2059659414 @default.
• W2005603603 cites W2061062195 @default.
• W2005603603 cites W2062351402 @default.
• W2005603603 cites W2070312129 @default.
• W2005603603 cites W2072073837 @default.
• W2005603603 cites W2078556042 @default.
• W2005603603 cites W2078841179 @default.
• W2005603603 cites W2080658541 @default.
• W2005603603 cites W2081193148 @default.
• W2005603603 cites W2083328029 @default.
• W2005603603 cites W2086364694 @default.
• W2005603603 cites W2088423137 @default.
• W2005603603 cites W2092510111 @default.
• W2005603603 cites W2095546640 @default.
• W2005603603 cites W2100282191 @default.
• W2005603603 cites W2105131842 @default.
• W2005603603 cites W2108725202 @default.
• W2005603603 cites W2109647778 @default.
• W2005603603 cites W2112327424 @default.
• W2005603603 cites W2112413552 @default.
• W2005603603 cites W2113072730 @default.
• W2005603603 cites W2118837944 @default.
• W2005603603 cites W2120594729 @default.
• W2005603603 cites W2128049766 @default.
• W2005603603 cites W2141134100 @default.
• W2005603603 cites W2144207870 @default.
• W2005603603 cites W2147205147 @default.
• W2005603603 cites W2148880214 @default.
• W2005603603 cites W2149587786 @default.
• W2005603603 cites W2150250410 @default.

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