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• W2005606653 abstract "It is commonly believed that the age-related decrease in the ratio CD28+/CD28− among CD8+ T cells reflects replicative senescence of the lymphocytes. To verify this claim we measured the proliferation of CD8+CD28+ and CD8+CD28− subsets by flow cytometry after PHA treatment of mononuclear lymphocytes from donors of different age, including centenarians. The fraction of CD28+ cells decreases from ca. 80 to 40% (young to centenarians, respectively) with increasing age of the donors. Stimulation by PHA results in an increase in the ratio of CD28+ relative to CD28− in all age groups. We found that not only CD8+CD28+ but also CD8+CD28− cells were capable of proliferation. Moreover, the fraction of proliferation-competent CD28− cells was higher in the older donors compared with the younger ones. While PHA treatment led to apoptosis (as measured by DNA content and caspase-3 activation) of more than 20% of all lymphocytes, in the CD8+ subset only ca. 10% died, irrespective of their CD28 status. Altogether, we showed over-representation of proliferating CD8+CD28− cells in aged people, which might not be particularly prone to undergo apoptosis." @default.
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• W2005606653 date "2004-04-01" @default.
• W2005606653 modified "2023-10-14" @default.
• W2005606653 title "Proliferation and apoptosis of human CD8+CD28+ and CD8+CD28− lymphocytes during aging" @default.
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• W2005606653 doi "https://doi.org/10.1016/j.exger.2003.09.026" @default.
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