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• W2005610478 abstract "The beneficial effects of agonists of growth hormone-releasing hormone receptor (GHRH-R) in heart failure models are associated with an increase in the number of ckit(+) cardiac stem cells (CSCs). The goal of the present study was to determine the presence of GHRH-R in CSCs, the effect of GHRH-R agonists on their proliferation and survival, and the mechanisms involved. We investigated the expression of GHRH-R in CSCs of different species and the effect of GHRH-R agonists on their cell proliferation and survival. GHRH-R is expressed in ckit(+) CSCs isolated from mouse, rat, and pig. Treatment of porcine CSCs with the GHRH-R agonist JI-38 significantly increased the rate of cell division. Similar results were observed with other GHRH-R agonists, MR-356 and MR-409. JI-38 exerted a protective effect on survival of porcine CSCs under conditions of oxidative stress induced by exposure to hydrogen peroxide. Treatment with JI-38 before exposure to peroxide significantly reduced cell death. A similar effect was observed with MR-356. Addition of GHRH-R agonists to porcine CSCs induced activation of ERK and AKT pathways as determined by increased expression of phospho-ERK and phospho-AKT. Inhibitors of ERK and AKT pathways completely reversed the effect of GHRH-R agonists on CSC proliferation. Our findings extend the observations of the expression of GHRH-R by CSCs and demonstrate that GHRH-R agonists have a direct effect on proliferation and survival of CSCs. These results support the therapeutic use of GHRH-R agonists for stimulating endogenous mechanisms for myocardial repair or for preconditioning of stem cells before transplantation." @default.
• W2005610478 created "2016-06-24" @default.
• W2005610478 creator A5007553347 @default.
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• W2005610478 date "2014-11-17" @default.
• W2005610478 modified "2023-10-01" @default.
• W2005610478 title "Agonists of growth hormone-releasing hormone stimulate self-renewal of cardiac stem cells and promote their survival" @default.
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• W2005610478 doi "https://doi.org/10.1073/pnas.1420375111" @default.
• W2005610478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4260571" @default.
• W2005610478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25404316" @default.
• W2005610478 hasPublicationYear "2014" @default.
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