FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005628265> ?p ?o ?g. }

• W2005628265 endingPage "13292" @default.
• W2005628265 startingPage "13284" @default.
• W2005628265 abstract "BtuF is the periplasmic binding protein (PBP) in the vitamin B12 uptake system in Escherichia coli where it is associated with the ABC transporter BtuCD. When the ligand binds, PBPs generally display large conformational changes, commonly termed the Venus flytrap mechanism. BtuF belongs to a group of PBPs that, on the basis of crystal structures, does not appear to display such behavior. Using 480 ns multicopy molecular dynamics simulations of apo and holo forms of the protein, we investigate the dynamics of BtuF. We find BtuF to be more flexible than previously assumed, displaying clear opening and closing motions which are more pronounced in the apo form. The protein behavior is compatible with a PBP functional model that postulates a closed conformation for the ligand-bound state, whereas the empty form fluctuates between open and closed conformations. Elastic network normal-mode analysis suggests that all BtuF-like PBPs are capable of similar opening and closing motions. It also makes the typical Venus flytrap domain motions a likely common means of how PBP−ABC transporter interaction could occur." @default.
• W2005628265 created "2016-06-24" @default.
• W2005628265 creator A5007009857 @default.
• W2005628265 creator A5025197741 @default.
• W2005628265 creator A5065556977 @default.
• W2005628265 date "2006-10-13" @default.
• W2005628265 modified "2023-10-16" @default.
• W2005628265 title "Opening and Closing Motions in the Periplasmic Vitamin B₁₂ Binding Protein BtuF" @default.
• W2005628265 cites W1964619751 @default.
• W2005628265 cites W1971330126 @default.
• W2005628265 cites W1975818112 @default.
• W2005628265 cites W2000544785 @default.
• W2005628265 cites W2006304581 @default.
• W2005628265 cites W2006322118 @default.
• W2005628265 cites W2016246519 @default.
• W2005628265 cites W2017361929 @default.
• W2005628265 cites W2023634624 @default.
• W2005628265 cites W2030193187 @default.
• W2005628265 cites W2031337884 @default.
• W2005628265 cites W2041787141 @default.
• W2005628265 cites W2055956723 @default.
• W2005628265 cites W2058963461 @default.
• W2005628265 cites W2059986155 @default.
• W2005628265 cites W2067174909 @default.
• W2005628265 cites W2068873942 @default.
• W2005628265 cites W2092085480 @default.
• W2005628265 cites W2116498327 @default.
• W2005628265 cites W2123768693 @default.
• W2005628265 cites W2140889378 @default.
• W2005628265 cites W2142785321 @default.
• W2005628265 cites W2163871231 @default.
• W2005628265 cites W4251838592 @default.
• W2005628265 doi "https://doi.org/10.1021/bi061280j" @default.
• W2005628265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17073449" @default.
• W2005628265 hasPublicationYear "2006" @default.
• W2005628265 type Work @default.
• W2005628265 sameAs 2005628265 @default.
• W2005628265 citedByCount "56" @default.
• W2005628265 countsByYear W20056282652012 @default.
• W2005628265 countsByYear W20056282652013 @default.
• W2005628265 countsByYear W20056282652014 @default.
• W2005628265 countsByYear W20056282652015 @default.
• W2005628265 countsByYear W20056282652016 @default.
• W2005628265 countsByYear W20056282652019 @default.
• W2005628265 countsByYear W20056282652021 @default.
• W2005628265 countsByYear W20056282652022 @default.
• W2005628265 countsByYear W20056282652023 @default.
• W2005628265 crossrefType "journal-article" @default.
• W2005628265 hasAuthorship W2005628265A5007009857 @default.
• W2005628265 hasAuthorship W2005628265A5025197741 @default.
• W2005628265 hasAuthorship W2005628265A5065556977 @default.
• W2005628265 hasConcept C104317684 @default.
• W2005628265 hasConcept C116569031 @default.
• W2005628265 hasConcept C12554922 @default.
• W2005628265 hasConcept C147597530 @default.
• W2005628265 hasConcept C149011108 @default.
• W2005628265 hasConcept C170493617 @default.
• W2005628265 hasConcept C17744445 @default.
• W2005628265 hasConcept C185592680 @default.
• W2005628265 hasConcept C199539241 @default.
• W2005628265 hasConcept C201663137 @default.
• W2005628265 hasConcept C2778775528 @default.
• W2005628265 hasConcept C44312359 @default.
• W2005628265 hasConcept C47701112 @default.
• W2005628265 hasConcept C547475151 @default.
• W2005628265 hasConcept C55493867 @default.
• W2005628265 hasConcept C59593255 @default.
• W2005628265 hasConcept C8010536 @default.
• W2005628265 hasConcept C86803240 @default.
• W2005628265 hasConceptScore W2005628265C104317684 @default.
• W2005628265 hasConceptScore W2005628265C116569031 @default.
• W2005628265 hasConceptScore W2005628265C12554922 @default.
• W2005628265 hasConceptScore W2005628265C147597530 @default.
• W2005628265 hasConceptScore W2005628265C149011108 @default.
• W2005628265 hasConceptScore W2005628265C170493617 @default.
• W2005628265 hasConceptScore W2005628265C17744445 @default.
• W2005628265 hasConceptScore W2005628265C185592680 @default.
• W2005628265 hasConceptScore W2005628265C199539241 @default.
• W2005628265 hasConceptScore W2005628265C201663137 @default.
• W2005628265 hasConceptScore W2005628265C2778775528 @default.
• W2005628265 hasConceptScore W2005628265C44312359 @default.
• W2005628265 hasConceptScore W2005628265C47701112 @default.
• W2005628265 hasConceptScore W2005628265C547475151 @default.
• W2005628265 hasConceptScore W2005628265C55493867 @default.
• W2005628265 hasConceptScore W2005628265C59593255 @default.
• W2005628265 hasConceptScore W2005628265C8010536 @default.
• W2005628265 hasConceptScore W2005628265C86803240 @default.
• W2005628265 hasIssue "44" @default.
• W2005628265 hasLocation W20056282651 @default.
• W2005628265 hasLocation W20056282652 @default.
• W2005628265 hasOpenAccess W2005628265 @default.
• W2005628265 hasPrimaryLocation W20056282651 @default.
• W2005628265 hasRelatedWork W1492304498 @default.
• W2005628265 hasRelatedWork W1509620090 @default.
• W2005628265 hasRelatedWork W1599719396 @default.
• W2005628265 hasRelatedWork W1726251904 @default.
• W2005628265 hasRelatedWork W2001329750 @default.
• W2005628265 hasRelatedWork W2052869590 @default.

• next