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- W2005630421 abstract "Congenital obstructive nephropathy constitutes one of the major causes of renal insufficiency in infants and children. This review addresses the need to define biomarkers that serve as surrogate end points for measuring the severity of obstruction, the evolution of renal maldevelopment and injury, and the response to medical or surgical intervention.The literature from the last 10 years was reviewed for biomarkers of congenital obstructive nephropathy. Sources of biomarkers included urine, blood, amniotic fluid, tissue and imaging techniques.Previous markers of congenital obstructive nephropathy include sonographic renal pelvic diameter, quantitative diuretic renography, and markers of glomerular and tubular function. Attempts to correlate renal histological changes with differential renal function have been disappointing. Immunohistochemical analysis and laser capture microscopy should improve specificity. Most promising is the application of new insights into the cellular response of the developing kidney to urinary tract obstruction. These findings include components of the renin-angiotensin system, transforming growth factor-beta 1, monocyte chemoattractant protein-1 and epidermal growth factor. Microarray studies show unique patterns of gene expression by the neonatal rat kidney subjected to ureteral obstruction, and proteomics should provide even more sensitive biomarkers of obstructive nephropathy.We must define the cellular and molecular bases of renal maldevelopment, focusing on the link between functional and developmental pathophysiology. These findings will lead to biomarkers that will optimize our management of congenital obstructive nephropathy." @default.
- W2005630421 created "2016-06-24" @default.
- W2005630421 creator A5073963481 @default.
- W2005630421 date "2004-09-01" @default.
- W2005630421 modified "2023-09-24" @default.
- W2005630421 title "BIOMARKERS OF CONGENITAL OBSTRUCTIVE NEPHROPATHY: PAST, PRESENT AND FUTURE" @default.
- W2005630421 cites W1481534080 @default.
- W2005630421 cites W1810640842 @default.
- W2005630421 cites W188708717 @default.
- W2005630421 cites W1970809499 @default.
- W2005630421 cites W1976541543 @default.
- W2005630421 cites W1979860840 @default.
- W2005630421 cites W1986235393 @default.
- W2005630421 cites W1991508087 @default.
- W2005630421 cites W1993417379 @default.
- W2005630421 cites W1997310530 @default.
- W2005630421 cites W1998767482 @default.
- W2005630421 cites W2000220463 @default.
- W2005630421 cites W2000432883 @default.
- W2005630421 cites W2002195240 @default.
- W2005630421 cites W2007439606 @default.
- W2005630421 cites W2011539833 @default.
- W2005630421 cites W2011978945 @default.
- W2005630421 cites W2015291356 @default.
- W2005630421 cites W2017440458 @default.
- W2005630421 cites W2017892284 @default.
- W2005630421 cites W2018267214 @default.
- W2005630421 cites W2024095951 @default.
- W2005630421 cites W2029881545 @default.
- W2005630421 cites W2033286207 @default.
- W2005630421 cites W2033399327 @default.
- W2005630421 cites W2034896797 @default.
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- W2005630421 cites W2036427538 @default.
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- W2005630421 doi "https://doi.org/10.1097/01.ju.0000129542.22043.ef" @default.
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